Anti-PARL Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PARL Antibody (CSB-PA880960ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Mitochondrial intramembrane cleaving protease PARL Antibody,Pbeta Antibody,PARL Antibody,PSARL Antibody

More alternative names for the antibody
Mitochondrial intramembrane cleaving protease PARL antibody|Mitochondrial intramembrane-cleaving protease PARL antibody|P-beta antibody|parl antibody|PARL_HUMAN antibody|Pbeta antibody|presenilin associated rhomboid-like antibody|Presenilins associated rhomboid-like protein antibody|PRO2207 antibody|PSARL antibody|PSARL1 antibody|PSENIP2 antibody|RHBDS1 antibody|Rhomboid 7 homolog 1 antibody
Anti-PARL antibody (ab45231)
Close sc-133884|sc-514836|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PARL Antibody

Catalogue No.

CSB-PA880960ESR1HU

Reactivity

Human

Immunogen

Recombinant human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

42 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:514191( Cow), Entrez Gene:55486( Human), Entrez Gene:381038( Mouse), Entrez Gene:287979( Rat), Omim:607858( Human), SwissProt:Q2KHV4( Cow), SwissProt:Q9H300( Human), SwissProt:Q5XJY4( Mouse), SwissProt:Q3B8P0( Rat), Unigene:478469( Human), Unigene:371737( Mouse), Unigene:7053( Rat)

Protein function

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. .

Protein sequence and domain

Belongs to the peptidase S54 family.

Protein post-translational modifications

P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. .

Protein cellular localization

Mitochondrion inner membrane ; Multi-pass membrane protein .; P-beta: Nucleus . Note=Translocated into the nucleus by an unknown mechanism (PubMed:17116872). .

Research area

All research areas>Synthesis and Degradation>PARL
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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