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Rabbit Anti-PARL Antibody (CSB-PA880960ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Mitochondrial intramembrane cleaving protease PARL Antibody,Pbeta Antibody,PARL Antibody,PSARL AntibodyMore alternative names for the antibody
Mitochondrial intramembrane cleaving protease PARL antibody|Mitochondrial intramembrane-cleaving protease PARL antibody|P-beta antibody|parl antibody|PARL_HUMAN antibody|Pbeta antibody|presenilin associated rhomboid-like antibody|Presenilins associated rhomboid-like protein antibody|PRO2207 antibody|PSARL antibody|PSARL1 antibody|PSENIP2 antibody|RHBDS1 antibody|Rhomboid 7 homolog 1 antibody
Anti-PARL antibody (ab45231)
Anti-PARL antibody (ab45231)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:514191( Cow), Entrez Gene:55486( Human), Entrez Gene:381038( Mouse), Entrez Gene:287979( Rat), Omim:607858( Human), SwissProt:Q2KHV4( Cow), SwissProt:Q9H300( Human), SwissProt:Q5XJY4( Mouse), SwissProt:Q3B8P0( Rat), Unigene:478469( Human), Unigene:371737( Mouse), Unigene:7053( Rat)
|Protein function|| |
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. .
|Protein sequence and domain|| |
Belongs to the peptidase S54 family.
|Protein post-translational modifications|| |
P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. .
|Protein cellular localization|| |
Mitochondrion inner membrane ; Multi-pass membrane protein .; P-beta: Nucleus . Note=Translocated into the nucleus by an unknown mechanism (PubMed:17116872). .
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CUSABIO BIOTECH CO.
|Product type|| |
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