Anti-PARP3 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PARP3 Antibody (CSB-PA017467ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

PARP-3 Antibody,hPARP-3 Antibody,ADP-ribosyltransferase diphtheria toxin-like 3 Antibody,ARTD3 Antibody,IRT1 Antibody,NAD(+) ADP-ribosyltransferase 3 Antibody,ADPRT-3 Antibody,Poly[ADP-ribose] synthase 3 Antibody,pADPRT-3 Antibody,PARP3 Antibody,ADPRT3 Antibody, ADPRTL3 Antibody

More alternative names for the antibody
ADP ribosyltransferase (NAD+; poly (ADP ribose) antibody|ADP ribosyltransferase diphtheria toxin like 3 antibody|ADPRT-3 antibody|ADPRT3 antibody|ADPRTL2 antibody|ADPRTL3 antibody|ARTD3 antibody|hPARP 3 antibody|hPARP-3 antibody|hPARP3 antibody|IRT 1 antibody|IRT1 antibody|NAD(+) ADP ribosyltransferase 3 antibody|NAD(+) ADP-ribosyltransferase 3 antibody|NAD+ ADP ribosyltransferase 3 antibody|pADPRT 3 antibody|pADPRT-3 antibody|pADPRT3 antibody|PARP 3 antibody|PARP-3 antibody|PARP3 antibody|PARP3_HUMAN antibody|Poly (ADP ribose) polymerase family, member 3 antibody|Poly (ADP ribose) synthetase 3 antibody|Poly [ADP-ribose] polymerase 3 antibody|Poly[ADP ribose] synthetase 3 antibody|Poly[ADP-ribose] synthase 3 antibody
Anti-PARP3 antibody (ab201099)
Close sc-133887|sc-390771|sc-390758|sc-30625|sc-130838|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PARP3 Antibody

Catalogue No.

CSB-PA017467ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Poly [ADP-ribose] polymerase 3 protein (294-533AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10039( Human), Entrez Gene:235587( Mouse), Entrez Gene:300985( Rat), Omim:607726( Human), SwissProt:Q9Y6F1( Human), Unigene:271742( Human)

Protein function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. .

Protein tissue specificity

Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

Protein sequence and domain

According to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.

Protein post-translational modifications

Auto-poly(ADP)-ribosylation.

Protein cellular localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.

Research area

All research areas>Transcription Regulators>PARP
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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