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Rabbit Anti-PAX4 Antibody (CSB-PA017490ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Paired box protein Pax-4 Antibody,PAX4 AntibodyMore alternative names for the antibody
KPD antibody|MGC129960 antibody|MODY9 antibody|Paired box 4 antibody|Paired box gene 4 antibody|paired box homeotic gene 4 antibody|Paired box protein Pax-4 antibody|Paired domain gene 4 antibody|Pax4 antibody|PAX4_HUMAN antibody
Anti-PAX4 antibody (ab42450)
Anti-PAX4 antibody (ab42450)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-1:2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Paired box protein Pax-4 protein (50-200AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5078( Human), Entrez Gene:18506( Mouse), Entrez Gene:83630( Rat), Omim:167413( Human), SwissProt:O43316( Human), SwissProt:P32115( Mouse), SwissProt:O88436( Rat), Unigene:129706( Human), Unigene:8026( Mouse), Unigene:14531( Rat)
|Protein function|| |
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
|Involvement in disease|| |
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, ketosis-prone (KPD) [MIM:612227]: An atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Maturity-onset diabetes of the young 9 (MODY9) [MIM:612225]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the paired homeobox family.
|Protein cellular localization|| |
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|Product type|| |
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