Anti-PAX4 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PAX4 Antibody (CSB-PA017490ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Paired box protein Pax-4 Antibody,PAX4 Antibody

More alternative names for the antibody
KPD antibody|MGC129960 antibody|MODY9 antibody|Paired box 4 antibody|Paired box gene 4 antibody|paired box homeotic gene 4 antibody|Paired box protein Pax-4 antibody|Paired domain gene 4 antibody|Pax4 antibody|PAX4_HUMAN antibody
Anti-PAX4 antibody (ab42450)
Close sc-27832|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-1:2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PAX4 Antibody

Catalogue No.

CSB-PA017490ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Paired box protein Pax-4 protein (50-200AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-1:2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

37 kDa

Purification

Antigen Affinity purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5078( Human), Entrez Gene:18506( Mouse), Entrez Gene:83630( Rat), Omim:167413( Human), SwissProt:O43316( Human), SwissProt:P32115( Mouse), SwissProt:O88436( Rat), Unigene:129706( Human), Unigene:8026( Mouse), Unigene:14531( Rat)

Protein function

Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.

Involvement in disease

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, ketosis-prone (KPD) [MIM:612227]: An atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Maturity-onset diabetes of the young 9 (MODY9) [MIM:612225]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the paired homeobox family.

Protein cellular localization

Nucleus.

Research area

All research areas>Homeodomain Proteins>Pax
(View all antibody categories related to Homeodomain Proteins)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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