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Rabbit Anti-PDCD4 Antibody (CSB-PA703610DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Neoplastic transformation inhibitor protein Antibody,Nuclear antigen H731-like Antibody,Protein 197/15a Antibody,PDCD4 Antibody,H731 AntibodyMore alternative names for the antibody
Death up-regulated gene protein antibody|Dug antibody|H731 antibody|Ma3 antibody|MGC33046 antibody|MGC33047 antibody|Neoplastic transformation inhibitor antibody|Neoplastic transformation inhibitor protein antibody|Nuclear antigen H731 antibody|Nuclear antigen H731 like antibody|Nuclear antigen H731 like protein antibody|Nuclear antigen H731-like antibody|PDCD 4 antibody|Pdcd4 antibody|PDCD4_HUMAN antibody|Programmed cell death 4 antibody|programmed cell death 4 (neoplastic transformation inhibitor) antibody|Programmed cell death protein 4 antibody|Protein 197/15a antibody|Protein MA-3 antibody|Tis antibody|Topoisomerase-inhibitor suppressed protein antibody
Anti-PDCD4 antibody (ab51495)
Anti-PDCD4 antibody (ab51495)
Recommended applications: ELISA, WB, IHC, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Programmed cell death protein 4 protein (1-260AA)
ELISA, WB, IHC, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:27250( Human), Entrez Gene:18569( Mouse), Entrez Gene:64031( Rat), Omim:608610( Human), SwissProt:Q53EL6( Human), SwissProt:Q61823( Mouse), SwissProt:Q9JID1( Rat), Unigene:711490( Human), Unigene:1605( Mouse), Unigene:375091( Mouse), Unigene:206228( Rat)
|Protein function|| |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). .
|Protein tissue specificity|| |
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. .
|Protein sequence and domain|| |
Belongs to the PDCD4 family. Binds EIF4A1 via both MI domains.
|Protein post-translational modifications|| |
Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. .; Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). .
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CUSABIO BIOTECH CO.
|Product type|| |
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