Anti-PDHX Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PDHX Antibody (CSB-PA017718ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex Antibody,E3-binding protein Antibody,E3BP Antibody,Lipoyl-containing pyruvate dehydrogenase complex component X Antibody,proX Antibody,PDHX Antibody,PDX1 Antibody

More alternative names for the antibody
70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody|AI481367 antibody|BOS_15094 antibody|Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody|Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody|DLAT antibody|DLDBP antibody|DLTA antibody|E3BP antibody|M2 antigen complex 70 kDa subunit antibody|MGC143185 antibody|mitochondrial antibody|ODP2_HUMAN antibody|OPDX antibody|PBC antibody|PDC-E2 antibody|PDCE2 antibody|PDX1 antibody|proX antibody|Pyruvate dehydrogenase complex component E2 antibody|Pyruvate dehydrogenase complex, component X antibody|RP23-203N8.2 antibody
Anti-Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5] (ab110333)
Close sc-365276|sc-271534|sc-166899|sc-16892|sc-271352|sc-32925|sc-16890|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PDHX Antibody

Catalogue No.

CSB-PA017718ESR2HU

Reactivity

Human

Immunogen

Recombinant human Pyruvate dehydrogenase protein X component, mitochondrial protein (1-300AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

54 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:12723( Cow), Entrez Gene:517402( Cow), Entrez Gene:1737( Human), Entrez Gene:8050( Human), Entrez Gene:235339( Mouse), Entrez Gene:27402( Mouse), Entrez Gene:311254( Rat), Entrez Gene:81654( Rat), SwissProt:P11180( Cow), SwissProt:P22439( Cow), SwissProt:O00330( Human), SwissProt:P10515( Human), SwissProt:Q8BKZ9( Mouse), SwissProt:Q8BMF4( Mouse), SwissProt:P08461( Rat), Unigene:335551( Human)

Protein function

Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.

Involvement in disease

Pyruvate dehydrogenase E3-binding protein deficiency (PDHXD) [MIM:245349]: A metabolic disorder characterized by decreased activity of the pyruvate dehydrogenase complex without observable reduction in the activities of enzymes E1, E2, or E3. Clinical features include hypotonia and psychomotor retardation. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the 2-oxoacid dehydrogenase family.

Protein post-translational modifications

Delipoylated at Lys-97 by SIRT4, delipoylation decreases the PHD complex activity. .

Protein cellular localization

Mitochondrion matrix.

Research area

All research areas>Signaling Intermediates>PDC-E2
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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