Anti-PDK2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PDK2 Antibody (CSB-PA618976ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Pyruvate dehydrogenase kinase isoform 2 Antibody,PDH kinase 2 Antibody, PDKII Antibody,PDK2 Antibody,PDHK2 Antibody

More alternative names for the antibody
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 antibody|mitochondrial antibody|PDHK2 antibody|PDK2 antibody|PDK2_HUMAN antibody|Pyruvate dehydrogenase kinase isoform 2 antibody|Pyruvate dehydrogenase kinase, isozyme 2 antibody|Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial antibody
Anti-PDK2 antibody [EPR1948Y] (ab68164)
Close sc-293179|sc-14486|sc-14484|sc-100534|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PDK2 Antibody

Catalogue No.

CSB-PA618976ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial protein (128-407AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

46 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5164( Human), Entrez Gene:18604( Mouse), Entrez Gene:81530( Rat), Omim:602525( Human), SwissProt:Q15119( Human), SwissProt:Q9JK42( Mouse), SwissProt:Q64536( Rat), Unigene:256667( Human), Unigene:29768( Mouse), Unigene:88597( Rat)

Protein function

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. .

Protein tissue specificity

Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. .

Protein sequence and domain

Belongs to the PDK/BCKDK protein kinase family.

Protein cellular localization

Mitochondrion matrix.

Research area

All research areas>Synthesis and Degradation>PDK
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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