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Rabbit Anti-PDK3 Antibody (CSB-PA613585ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Alternative names:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3 Antibody,mitochondrial Antibody,Pyruvate dehydrogenase kinase isoform 3 Antibody,PDK3 Antibody,PDHK3 Antibody More alternative names for the antibody
[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial antibody|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 antibody|CMTX6 antibody|GS1-358P8.4 antibody|mitochondrial antibody|PDK3 antibody|PDK3_HUMAN antibody|Pyruvate dehydrogenase kinase isoenzyme 3 antibody|Pyruvate dehydrogenase kinase isoform 3 antibody|Pyruvate dehydrogenase kinase isozyme 3 antibody|Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial antibody
Anti-PDK3 antibody (ab154549)
Anti-PDK3 antibody (ab154549)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (137-406AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5165( Human), Entrez Gene:236900( Mouse), Entrez Gene:296849( Rat), Omim:602526( Human), SwissProt:Q15120( Human), SwissProt:Q922H2( Mouse), Unigene:296031( Human), Unigene:12775( Mouse), Unigene:18101( Rat)
|Protein function|| |
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. .
|Protein tissue specificity|| |
Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. .
|Involvement in disease|| |
Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6) [MIM:300905]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the PDK/BCKDK protein kinase family.
|Protein cellular localization|| |
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|Product type|| |
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