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Rabbit Anti-PEX19 Antibody (CSB-PA017802DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Peroxisomal biogenesis factor 19 Antibody,33 kDa housekeeping protein Antibody,Peroxin-19 Antibody,Peroxisomal farnesylated protein Antibody,PEX19 Antibody,HK33 Antibody,PXF Antibody,OK/SW-cl.22 AntibodyMore alternative names for the antibody
33 kDa housekeeping protein antibody|D1S2223E antibody|HK33 antibody|Housekeeping gene 33kD antibody|OK/SW-cl.22 antibody|PBD12A antibody|Peroxin 19 antibody|Peroxin-19 antibody|Peroxisomal biogenesis factor 19 antibody|Peroxisomal farnesylated protein antibody|PEX19 antibody|PEX19_HUMAN antibody|PMP1 antibody|PMPI antibody|PXF antibody|PXMP1 antibody
Anti-PEX19 antibody [EPR9266(B)] (ab137072)
Anti-PEX19 antibody [EPR9266(B)] (ab137072)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Peroxisomal biogenesis factor 19 protein (1-299AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5824( Human), Entrez Gene:19298( Mouse), Entrez Gene:289233( Rat), Omim:600279( Human), SwissProt:P40855( Human), SwissProt:Q8VCI5( Mouse), SwissProt:Q9QYU1( Rat), Unigene:517232( Human), Unigene:247764( Mouse), Unigene:203104( Rat), Unigene:225447( Rat)
|Protein function|| |
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .
|Protein tissue specificity|| |
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. .
|Involvement in disease|| |
Peroxisome biogenesis disorder complementation group 14 (PBD-CG14) [MIM:614886]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). . Note=The disease is caused by mutations affecting the gene represented in this entry.; Peroxisome biogenesis disorder 12A (PBD12A) [MIM:614886]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peroxin-19 family.
|Protein cellular localization|| |
Cytoplasm . Peroxisome membrane ; Lipid-anchor ; Cytoplasmic side . Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes. .
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CUSABIO BIOTECH CO.
|Product type|| |
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