Anti-PIAS1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PIAS1 Antibody (CSB-PA017957ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

DEAD/H box-binding protein 1 Antibody,Gu-binding protein Antibody,GBP Antibody,Protein inhibitor of activated STAT protein 1 Antibody,RNA helicase II-binding protein Antibody,PIAS1 Antibody,DDXBP1 Antibody

More alternative names for the antibody
AR interacting protein antibody|DDXBP1 antibody|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 antibody|DEAD/H box binding protein 1 antibody|DEAD/H box-binding protein 1 antibody|E3 SUMO-protein ligase PIAS1 antibody|GBP antibody|Gu binding protein antibody|Gu-binding protein antibody|GU/RH-II antibody|Pias1 antibody|PIAS1_HUMAN antibody|Protein inhibitor of activated STAT protein 1 antibody|Protein inhibitor of activated STAT, 1 antibody|RNA helicase II binding protein antibody|RNA helicase II-binding protein antibody|Zinc finger, MIZ-type containing 3 antibody|ZMIZ3 antibody
Anti-PIAS1 antibody – ChIP Grade (ab32219)
Close sc-8152|sc-365127|sc-14016|sc-271172|sc-8153|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PIAS1 Antibody

Catalogue No.

CSB-PA017957ESR1HU

Reactivity

Human

Immunogen

Recombinant human E3 SUMO-protein ligase PIAS1 protein (422-651AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

71 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:427514( Chicken), Entrez Gene:8554( Human), Entrez Gene:56469( Mouse), Entrez Gene:300772( Rat), Omim:603566( Human), SwissProt:O75925( Human), SwissProt:O88907( Mouse), Unigene:162458( Human), Unigene:431253( Mouse), Unigene:479179( Mouse)

Protein function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at’Lys-65′ and ‘Lys-160’) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). .

Protein tissue specificity

Expressed in numerous tissues with highest level in testis. .

Protein sequence and domain

Belongs to the PIAS family. The LXXLL motif is a transcriptional coregulator signature.; The SP-RING-type domain is required for promoting EKLF sumoylation.

Protein post-translational modifications

Sumoylated. .; Dimethylated by PRMT1 at Arg-303 in the late phase of interferon gamma (IFN-gamma) signaling, leading to preferential interaction with STAT1 and thus resulting in release of STAT1 from its target gene.

Protein cellular localization

Nucleus speckle . Nucleus, PML body . Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.

Research area

All research areas>Signaling Intermediates>PIAS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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