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Rabbit Anti-PIAS2 Antibody (CSB-PA017958DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Androgen receptor-interacting protein 3 Antibody,ARIP3 Antibody,DAB2-interacting protein Antibody, DIP Antibody,Msx-interacting zinc finger protein Antibody,Miz1 Antibody,PIAS-NY protein Antibody,Protein inhibitor of activated STAT x Antibody,Protein inhibitor of activated STAT2 Antibody,PIAS2 Antibody,PIASX AntibodyMore alternative names for the antibody
Androgen receptor interacting protein 3 antibody|Androgen receptor-interacting protein 3 antibody|ARIP3 antibody|DAB2 interacting protein antibody|DAB2-interacting protein antibody|DIP antibody|E3 SUMO protein ligase PIAS2 antibody|E3 SUMO-protein ligase PIAS2 antibody|MIZ antibody|Miz1 antibody|Msx interacting zinc finger protein antibody|Msx-interacting zinc finger protein antibody|PIAS NY protein antibody|PIAS-NY protein antibody|PIAS2 antibody|PIAS2_HUMAN antibody|PIASX antibody|PIASX-ALPHA antibody|PIASX-BETA antibody|Protein inhibitor of activated STAT x antibody|Protein inhibitor of activated STAT, 2 antibody|Protein inhibitor of activated STAT2 antibody|SIZ2 antibody|Zinc finger, MIZ-type containing 4 antibody|ZMIZ4 antibody
Anti-PIAS2 antibody (ab155556)
Anti-PIAS2 antibody (ab155556)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 SUMO-protein ligase PIAS2 protein (532-621AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:9063( Human), Entrez Gene:17344( Mouse), Entrez Gene:83422( Rat), Omim:603567( Human), SwissProt:O75928( Human), SwissProt:Q8C5D8( Mouse), SwissProt:Q6AZ28( Rat), Unigene:657844( Human), Unigene:6370( Mouse), Unigene:227054( Rat)
|Protein function|| |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at’Lys-65′ and ‘Lys-160’. .
|Protein tissue specificity|| |
Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs. .
|Protein sequence and domain|| |
Belongs to the PIAS family. The LXXLL motif is a transcriptional coregulator signature.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Nucleus speckle . Nucleus, PML body . Nucleus . Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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