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Rabbit Anti-PIAS3 Antibody (CSB-PA896765DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Protein inhibitor of activated STAT protein 3 Antibody,PIAS3 AntibodyMore alternative names for the antibody
E3 SUMO protein ligase PIAS 3 antibody|E3 SUMO protein ligase PIAS3 antibody|E3 SUMO-protein ligase PIAS3 antibody|FLJ14651 antibody|OTTHUMP00000015586 antibody|OTTHUMP00000015587 antibody|PIAS 3 antibody|Pias3 antibody|PIAS3 protein antibody|PIAS3_HUMAN antibody|Protein inhibitor of activated STAT 3 antibody|Protein inhibitor of activated STAT protein 3 antibody|Protein inhibitor of activated STAT3 antibody|Zinc finger MIZ type containing 5 antibody|ZMIZ 5 antibody|ZMIZ5 antibody
Anti-PIAS3 antibody (ab22856)
Anti-PIAS3 antibody (ab22856)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 SUMO-protein ligase PIAS3 protein (399-628AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:10401( Human), Entrez Gene:229615( Mouse), Entrez Gene:83614( Rat), Omim:605987( Human), SwissProt:Q9Y6X2( Human), SwissProt:O54714( Mouse), SwissProt:O70260( Rat), Unigene:435761( Human), Unigene:1635( Mouse), Unigene:14548( Rat)
|Protein function|| |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). .
|Protein tissue specificity|| |
Widely expressed. .
|Protein sequence and domain|| |
Belongs to the PIAS family. The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.; The LXXLL motif is a transcriptional coregulator signature.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cytoplasm . Nucleus . Nucleus speckle . Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. .
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CUSABIO BIOTECH CO.
|Product type|| |
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