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Rabbit Anti-PIEZO1 Antibody (CSB-PA852881ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Piezo-type mechanosensitive ion channel component 1 Antibody,Membrane protein induced by beta-amyloid treatment Antibody,Mib Antibody,Protein FAM38A Antibody,PIEZO1 Antibody,FAM38A Antibody,KIAA0233 AntibodyMore alternative names for the antibody
DHS antibody|Fam38a antibody|Family with sequence similarity 38 member A antibody|KIAA0233 antibody|Membrane protein induced by beta-amyloid treatment antibody|Mib antibody|PIEZ1_HUMAN antibody|Piezo-type mechanosensitive ion channel component 1 antibody|PIEZO1 antibody|Protein FAM38A antibody|Protein FAM38B antibody|Protein PIEZO1 antibody
Anti-FAM38A antibody (ab128245)
Anti-FAM38A antibody (ab128245)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:9780( Human), Entrez Gene:234839( Mouse), Entrez Gene:361430( Rat), Omim:611184( Human), SwissProt:Q92508( Human), SwissProt:E2JF22( Mouse), SwissProt:Q0KL00( Rat), Unigene:377001( Human), Unigene:592074( Human), Unigene:37324( Mouse), Unigene:20892( Rat)
|Protein function|| |
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). .
|Protein tissue specificity|| |
Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). .
|Involvement in disease|| |
Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema (DHS1) [MIM:194380]: An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. DHS erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. DHS patients typically exhibit mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Patients may also show perinatal edema and pseudohyperkalemia due to loss of potassium from red cells stored at room temperature. A minor proportion of red cells appear as stomatocytes on blood films. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur. The course of DHS is frequently associated with iron overload, which may lead to hepatosiderosis. . Note=The disease is caused by mutations affecting the gene represented in this entry. All disease-causing mutations characterized so far produce a gain-of-function phenotype, mutated channels exhibiting increased cation transport in erythroid cells, that could be due to slower channel inactivation rate compared to the wild-type protein.; Lymphedema, hereditary, 3 (LMPH3) [MIM:616843]: A severe form of lymphedema, a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. LMPH3 manifests as generalized lymphatic dysplasia, characterized by uniform, widespread lymphedema affecting all segments of the body, with systemic involvement such as intestinal and/or pulmonary lymphangiectasia, pleural effusions, chylothoraces and/or pericardial effusions, and with a high incidence of non-immune hydrops fetalis. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the PIEZO (TC 1.A.75) family.
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane . Cell membrane ; Multi-pass membrane protein . Cell projection, lamellipodium membrane . Note=In erythrocytes, located in the plasma membrane (PubMed:22529292, PubMed:23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (PubMed:25119035). .
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|Product type|| |
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