Anti-PIP5K1A Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PIP5K1A Antibody (CSB-PA859110ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Antibody,PIP5K1-alpha Antibody,PtdIns(4)P-5-kinase 1 alpha Antibody,68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha Antibody,Phosphatidylinositol 4-phosphate 5-kinase type I alpha Antibody,PIP5KIalpha Antibody,PIP5K1A Antibody

More alternative names for the antibody
68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha antibody|Phosphatidylinositol 4 phosphate 5 kinase type I alpha antibody|Phosphatidylinositol-4-phosphate 5-kinase type I alpha antibody|Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha antibody|PI4P5K Ia antibody|PI51A_HUMAN antibody|PIP5K A antibody|PIP5K1-alpha antibody|Pip5k1a antibody|PIP5KIalpha antibody|PtdIns(4)P-5-kinase 1 alpha antibody
Anti-PIP5K1 alpha antibody (ab137441)
Close sc-11772|sc-376634|sc-11774|sc-377021|sc-515416|sc-376195|sc-398687|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-PIP5K1A Antibody

Catalogue No.

CSB-PA859110ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha protein (293-562AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

62 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:100125224( Cow), Entrez Gene:8394( Human), Entrez Gene:100624272( Pig), Omim:603275( Human), SwissProt:Q99755( Human), Unigene:655131( Human), Unigene:707569( Human)

Protein function

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. .

Protein tissue specificity

Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.

Protein cellular localization

Cell membrane. Cytoplasm . Nucleus speckle. Cell projection, ruffle. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.

Research area

All research areas>Kinases and Phosphatases>PIPK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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