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Rabbit Anti-PIWIL1 Antibody (CSB-PA846642ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Piwi-like protein 1 Antibody,PIWIL1 Antibody,HIWI AntibodyMore alternative names for the antibody
HIWI antibody|MIWI antibody|Piwi (Drosophila) like 1 antibody|PIWI antibody|Piwi homolog antibody|Piwi like 1 (drosophila) antibody|Piwi like 1 antibody|Piwi-like protein 1 antibody|PIWIL1 antibody|PIWL1_HUMAN antibody
Anti-PIWIL1 antibody (ab12337)
Anti-PIWIL1 antibody (ab12337)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Piwi-like protein 1 protein (390-690AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:9271( Human), Entrez Gene:57749( Mouse), Entrez Gene:363912( Rat), Omim:605571( Human), SwissProt:Q96J94( Human), SwissProt:Q9JMB7( Mouse), Unigene:405659( Human), Unigene:272720( Mouse), Unigene:131387( Rat)
|Protein function|| |
Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. .; Isoform 3: May be a negative developmental regulator (PubMed:12037681, PubMed:16287078). .
|Protein tissue specificity|| |
Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells. .
|Protein sequence and domain|| |
Belongs to the argonaute family. Piwi subfamily. The PAZ domain specifically recognizes binds the 2′-O-methylated 3′-end of piRNAs.
|Protein post-translational modifications|| |
Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule. .
|Protein cellular localization|| |
Cytoplasm . Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body. .
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CUSABIO BIOTECH CO.
|Product type|| |
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