Anti-PKD2L1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PKD2L1 Antibody (CSB-PA865199DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Polycystin-2 homolog;Polycystin-2L1;Polycystin-L;Polycystin-L1;PKD2L1;PKD2L Antibody, PKDL Antibody,TRPP3 Antibody

More alternative names for the antibody

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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PKD2L1 Antibody

Catalogue No.

CSB-PA865199DSR2HU

Reactivity

Human

Immunogen

Recombinant human Polycystic kidney disease 2-like 1 protein (561-805AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

91 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Protein function

Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. .

Protein tissue specificity

Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. .

Protein sequence and domain

Belongs to the polycystin family. The EF-hand domain probably mediates calcium-binding. It is not required for channel activation (PubMed:11959145).

Protein cellular localization

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum . Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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