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Rabbit Anti-PLCD4 Antibody (CSB-PA866264ESR1HU)
Supplier: CUSABIO BIOTECH CO.
1-phosphatidylinositol 4 Antibody,5-bisphosphate phosphodiesterase delta-4 Antibody,hPLCD4 Antibody,Phosphoinositide phospholipase C-delta-4 Antibody,Phospholipase C-delta-4 Antibody,PLC-delta-4 Antibody,PLCD4 AntibodyMore alternative names for the antibody
1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4 antibody|1-phosphatidylinositol 4 antibody|5-bisphosphate phosphodiesterase delta-4 antibody|hPLCD4 antibody|MGC12837 antibody|Phosphoinositide phospholipase C delta 4 antibody|Phosphoinositide phospholipase C-delta-4 antibody|Phospholipase C delta 4 antibody|Phospholipase C-delta-4 antibody|PLC delta 4 antibody|PLC delta4 antibody|PLC-delta-4 antibody|PLCD4 antibody|PLCD4_HUMAN antibody
Anti-PLCD4 antibody (ab169169)
Anti-PLCD4 antibody (ab169169)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein (1-290AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:84812( Human), Entrez Gene:100171640( Orangutan), Entrez Gene:397119( Pig), Omim:605939( Human), SwissProt:Q9BRC7( Human), SwissProt:Q5RET0( Orangutan), SwissProt:Q8SPR7( Pig), Unigene:632528( Human)
|Protein function|| |
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. .
|Protein tissue specificity|| |
Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. .
|Protein sequence and domain|| |
The PDZ-binding motif mediates the interaction with GRIP1.; The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.; The PH domain is not a critical determinant of the membrane localization.
|Protein cellular localization|| |
Membrane ; Peripheral membrane protein . Nucleus . Cytoplasm . Endoplasmic reticulum . Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
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CUSABIO BIOTECH CO.
|Product type|| |
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