Anti-PLCD4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PLCD4 Antibody (CSB-PA866264ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

1-phosphatidylinositol 4 Antibody,5-bisphosphate phosphodiesterase delta-4 Antibody,hPLCD4 Antibody,Phosphoinositide phospholipase C-delta-4 Antibody,Phospholipase C-delta-4 Antibody,PLC-delta-4 Antibody,PLCD4 Antibody

More alternative names for the antibody
1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4 antibody|1-phosphatidylinositol 4 antibody|5-bisphosphate phosphodiesterase delta-4 antibody|hPLCD4 antibody|MGC12837 antibody|Phosphoinositide phospholipase C delta 4 antibody|Phosphoinositide phospholipase C-delta-4 antibody|Phospholipase C delta 4 antibody|Phospholipase C-delta-4 antibody|PLC delta 4 antibody|PLC delta4 antibody|PLC-delta-4 antibody|PLCD4 antibody|PLCD4_HUMAN antibody
Anti-PLCD4 antibody (ab169169)
Close sc-373875|sc-30063|sc-30830|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PLCD4 Antibody

Catalogue No.

CSB-PA866264ESR1HU

Reactivity

Human

Immunogen

Recombinant human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein (1-290AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

87 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:84812( Human), Entrez Gene:100171640( Orangutan), Entrez Gene:397119( Pig), Omim:605939( Human), SwissProt:Q9BRC7( Human), SwissProt:Q5RET0( Orangutan), SwissProt:Q8SPR7( Pig), Unigene:632528( Human)

Protein function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. .

Protein tissue specificity

Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. .

Protein sequence and domain

The PDZ-binding motif mediates the interaction with GRIP1.; The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.; The PH domain is not a critical determinant of the membrane localization.

Protein cellular localization

Membrane ; Peripheral membrane protein . Nucleus . Cytoplasm . Endoplasmic reticulum . Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Research area

All research areas>Synthesis and Degradation>PLC
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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