Anti-PLK2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PLK2 Antibody (CSB-PA885770ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Polo-like kinase 2 Antibody,PLK-2 Antibody, hPlk2 Antibody,Serine/threonine-protein kinase SNK Antibody,hSNK Antibody,Serum-inducible kinase Antibody,PLK2 Antibody,SNK Antibody

More alternative names for the antibody
hPlk2 antibody|hSNK antibody|PLK-2 antibody|Plk2 antibody|PLK2_HUMAN antibody|Polo like kinase 2 antibody|Polo-like kinase 2 antibody|Serine/threonine protein kinase PLK2 antibody|Serine/threonine protein kinase SNK antibody|Serine/threonine-protein kinase PLK2 antibody|Serine/threonine-protein kinase SNK antibody|Serum Induced Kinase antibody|Serum-inducible kinase antibody|SNK antibody
Anti-PLK2 antibody (ab71311)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PLK2 Antibody

Catalogue No.

CSB-PA885770ESR1HU

Reactivity

Human

Immunogen

Recombinant human Serine/threonine-protein kinase PLK2 protein (336-685AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

78 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10769( Human), Entrez Gene:20620( Mouse), Entrez Gene:83722( Rat), Omim:607023( Human), SwissProt:Q9NYY3( Human), SwissProt:P53351( Mouse), SwissProt:Q9R012( Rat), Unigene:398157( Human), Unigene:658132( Human), Unigene:380( Mouse), Unigene:12100( Rat)

Protein function

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. .

Protein tissue specificity

Expressed at higher level in the fetal lung, kidney, spleen and heart. .

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity).

Protein post-translational modifications

Catalytic activity is enhanced by phosphorylation of Thr-239. .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

Research area

All research areas>Kinases and Phosphatases>Snk
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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