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Rabbit Anti-PLK2 Antibody (CSB-PA885770ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Polo-like kinase 2 Antibody,PLK-2 Antibody, hPlk2 Antibody,Serine/threonine-protein kinase SNK Antibody,hSNK Antibody,Serum-inducible kinase Antibody,PLK2 Antibody,SNK AntibodyMore alternative names for the antibody
hPlk2 antibody|hSNK antibody|PLK-2 antibody|Plk2 antibody|PLK2_HUMAN antibody|Polo like kinase 2 antibody|Polo-like kinase 2 antibody|Serine/threonine protein kinase PLK2 antibody|Serine/threonine protein kinase SNK antibody|Serine/threonine-protein kinase PLK2 antibody|Serine/threonine-protein kinase SNK antibody|Serum Induced Kinase antibody|Serum-inducible kinase antibody|SNK antibody
Anti-PLK2 antibody (ab71311)
Anti-PLK2 antibody (ab71311)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Serine/threonine-protein kinase PLK2 protein (336-685AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:10769( Human), Entrez Gene:20620( Mouse), Entrez Gene:83722( Rat), Omim:607023( Human), SwissProt:Q9NYY3( Human), SwissProt:P53351( Mouse), SwissProt:Q9R012( Rat), Unigene:398157( Human), Unigene:658132( Human), Unigene:380( Mouse), Unigene:12100( Rat)
|Protein function|| |
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. .
|Protein tissue specificity|| |
Expressed at higher level in the fetal lung, kidney, spleen and heart. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity).
|Protein post-translational modifications|| |
Catalytic activity is enhanced by phosphorylation of Thr-239. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
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CUSABIO BIOTECH CO.
|Product type|| |
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