Anti-PNPLA2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PNPLA2 Antibody (CSB-PA836180ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Adipose triglyceride lipase Antibody,Calcium-independent phospholipase A2 Antibody,Desnutrin Antibody,IPLA2-zeta Antibody,Pigment epithelium-derived factor Antibody,Transport-secretion protein 2 Antibody,TTS2 Antibody,PNPLA2 Antibody,ATGL Antibody

More alternative names for the antibody
1110001C14Rik antibody|Adipose triglyceride lipase antibody|ATGL antibody|ATGL DESNUTRIN antibody|Calcium independent phospholipase A2 antibody|Calcium-independent phospholipase A2 antibody|Desnutrin antibody|EC 3.1.1.3 antibody|FP17548 antibody|IPLA2 zeta antibody|IPLA2-zeta antibody|PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 antibody|Patatin-like phospholipase domain-containing protein 2 antibody|PEDF R antibody|PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA antibody|Pigment epithelium derived factor antibody|Pigment epithelium-derived factor antibody|plpl antibody|plpl2 antibody|PLPL2_HUMAN antibody|Pnpla2 antibody|Transport secretion protein 2 antibody|Transport secretion protein 2.2 antibody|Transport-secretion protein 2 antibody|Triglyceride hydrolase antibody|TTS 2.2 antibody|TTS2 antibody|TTS2.2 antibody|ZETA antibody
Anti-Adipose Triglyceride Lipase antibody [EPR3444(2)] (ab109251)
Close sc-365278|sc-67355|sc-50222|sc-50223|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PNPLA2 Antibody

Catalogue No.

CSB-PA836180ESR1HU

Reactivity

Human

Immunogen

Recombinant human Patatin-like phospholipase domain-containing protein 2 protein (265-504AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

55 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:57104( Human), Entrez Gene:66853( Mouse), Entrez Gene:361676( Rat), Omim:609059( Human), SwissProt:Q96AD5( Human), SwissProt:Q8BJ56( Mouse), SwissProt:P0C548( Rat), Unigene:654697( Human), Unigene:29998( Mouse), Unigene:19196( Rat)

Protein function

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. .

Protein tissue specificity

Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). .

Involvement in disease

Note=Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2. .; Neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]: Neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation. .

Protein cellular localization

Lipid droplet. Cell membrane; Single-pass type II membrane protein.

Research area

All research areas>Synthesis and Degradation>ATGL
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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