Anti-POC1A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-POC1A Antibody (CSB-PA822753ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

POC1 centriolar protein homolog A Antibody,Pix2 Antibody,Proteome of centriole protein 1A Antibody,WD repeat-containing protein 51A Antibody,POC1A Antibody,WDR51A Antibody

More alternative names for the antibody
Pix2 antibody|POC1 centriolar protein homolog A (Chlamydomonas) antibody|POC1 centriolar protein homolog A antibody|Poc1a antibody|POC1A_HUMAN antibody|WD repeat containing protein 51A antibody|WD repeat domain 51A antibody|WD repeat-containing protein 51A antibody
Anti-WDR51A antibody – N-terminal (ab174167)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-POC1A Antibody

Catalogue No.

CSB-PA822753ESR2HU

Reactivity

Human

Immunogen

Recombinant human POC1 centriolar protein homolog A protein (138-407AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

45 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:25886( Human), Entrez Gene:70235( Mouse), Entrez Gene:406322( Zebrafish), Omim:614783( Human), SwissProt:Q8NBT0( Human), SwissProt:Q8JZX3( Mouse), SwissProt:Q7ZVF0( Zebrafish), Unigene:476306( Human), Unigene:23054( Mouse), Unigene:150982( Zebrafish)

Protein function

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation. .

Involvement in disease

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [MIM:614813]: A syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed. . Note=The disease is caused by mutations affecting the gene represented in this entry. Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis.

Protein sequence and domain

Belongs to the WD repeat POC1 family.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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