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Rabbit Anti-POC1B Antibody (CSB-PA855046ESR2HU)
Supplier: CUSABIO BIOTECH CO.
POC1 centriolar protein homolog B Antibody,Pix1 Antibody,Proteome of centriole protein 1B Antibody,WD repeat-containing protein 51B Antibody,POC1B Antibody,WDR51B AntibodyMore alternative names for the antibody
4933430F16Rik antibody|FLJ14923 antibody|FLJ41111 antibody|Pix1 antibody|POC1 centriolar protein homolog B (Chlamydomonas) antibody|POC1 centriolar protein homolog B antibody|POC1B antibody|POC1B_HUMAN antibody|TUWD12 antibody|WD repeat containing protein 51B antibody|WD repeat domain 51B antibody|WD repeat-containing protein 51B antibody|WDR51B antibody
Anti-WDR51B antibody (ab84919)
Anti-WDR51B antibody (ab84919)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human POC1 centriolar protein homolog B protein (299-478AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:282809( Human), Entrez Gene:382406( Mouse), Entrez Gene:100362836( Rat), Omim:614784( Human), SwissProt:Q8TC44( Human), SwissProt:Q8BHD1( Mouse), SwissProt:D3ZW91( Rat), Unigene:25130( Human), Unigene:604487( Human), Unigene:440656( Mouse)
|Protein function|| |
Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). .
|Protein tissue specificity|| |
Expressed in the retina. .
|Involvement in disease|| |
Cone-rod dystrophy 20 (CORD20) [MIM:615973]: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the WD repeat POC1 family.
|Protein post-translational modifications|| |
Phosphorylated in mitotic cells that may be mediated by CDK1. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. .
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CUSABIO BIOTECH CO.
|Product type|| |
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