Anti-POC1B Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-POC1B Antibody (CSB-PA855046ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

POC1 centriolar protein homolog B Antibody,Pix1 Antibody,Proteome of centriole protein 1B Antibody,WD repeat-containing protein 51B Antibody,POC1B Antibody,WDR51B Antibody

More alternative names for the antibody
4933430F16Rik antibody|FLJ14923 antibody|FLJ41111 antibody|Pix1 antibody|POC1 centriolar protein homolog B (Chlamydomonas) antibody|POC1 centriolar protein homolog B antibody|POC1B antibody|POC1B_HUMAN antibody|TUWD12 antibody|WD repeat containing protein 51B antibody|WD repeat domain 51B antibody|WD repeat-containing protein 51B antibody|WDR51B antibody
Anti-WDR51B antibody (ab84919)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-POC1B Antibody

Catalogue No.

CSB-PA855046ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human POC1 centriolar protein homolog B protein (299-478AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

53 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:282809( Human), Entrez Gene:382406( Mouse), Entrez Gene:100362836( Rat), Omim:614784( Human), SwissProt:Q8TC44( Human), SwissProt:Q8BHD1( Mouse), SwissProt:D3ZW91( Rat), Unigene:25130( Human), Unigene:604487( Human), Unigene:440656( Mouse)

Protein function

Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). .

Protein tissue specificity

Expressed in the retina. .

Involvement in disease

Cone-rod dystrophy 20 (CORD20) [MIM:615973]: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the WD repeat POC1 family.

Protein post-translational modifications

Phosphorylated in mitotic cells that may be mediated by CDK1. .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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