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Rabbit Anti-PPP1R8 Antibody (CSB-PA618641DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Nuclear inhibitor of protein phosphatase 1 Antibody,NIPP-1 Antibody,Protein phosphatase 1 regulatory inhibitor subunit 8 Antibody,Activator of RNA decay Antibody,ARD-1 Antibody,PPP1R8 Antibody,ARD1 Antibody,NIPP1 AntibodyMore alternative names for the antibody
Activator of RNA decay antibody|ARD 1 antibody|ARD-1 antibody|ARD1 antibody|Homolog of E.coli RNase E antibody|NIPP 1 antibody|NIPP-1 antibody|NIPP1 antibody|Nuclear inhibitor of protein phosphatase 1 antibody|nuclear inhibitor of protein phosphatase-1 alpha antibody|Nuclear subunit of PP1 antibody|PP1R8_HUMAN antibody|PPP1R8 antibody|PRO2047 antibody|Protein phosphatase 1 regulatory inhibitor subunit 8 antibody|Protein phosphatase 1 regulatory subunit 8 antibody|RNase E antibody|RNase E, E. coli, homolog of antibody
Anti-NIPP1 antibody (ab129286)
Anti-NIPP1 antibody (ab129286)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=282319" target="_blank">Entrez Gene:282319( Cow)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5511" target="_blank">Entrez Gene:5511( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100336" target="_blank">Entrez Gene:100336( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=313030" target="_blank">Entrez Gene:313030( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/602636" target="_blank">Omim:602636( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q28147" target="_blank">SwissProt:Q28147( Cow)</a>, <a href="http://www.uniprot.org/uniprot/Q12972" target="_blank">SwissProt:Q12972( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q8R3G1" target="_blank">SwissProt:Q8R3G1( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=533474" target="_blank">Unigene:533474( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=105230" target="_blank">Unigene:105230( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=16580" target="_blank">Unigene:16580( Rat)</a>
|Protein function|| |
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
|Protein tissue specificity|| |
Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. .
|Protein sequence and domain|| |
Has a basic N- and C-terminal and an acidic central domain.; The FHA domain mediates interactions with threonine-phosphorylated MELK.
|Protein post-translational modifications|| |
May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA. .
|Protein cellular localization|| |
Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="https://antibodyplus.com/product-tag/NIPP/">NIPP</a><br><a href="https://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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