Anti-PPP1R8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PPP1R8 Antibody (CSB-PA618641DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Nuclear inhibitor of protein phosphatase 1 Antibody,NIPP-1 Antibody,Protein phosphatase 1 regulatory inhibitor subunit 8 Antibody,Activator of RNA decay Antibody,ARD-1 Antibody,PPP1R8 Antibody,ARD1 Antibody,NIPP1 Antibody

More alternative names for the antibody
Activator of RNA decay antibody|ARD 1 antibody|ARD-1 antibody|ARD1 antibody|Homolog of E.coli RNase E antibody|NIPP 1 antibody|NIPP-1 antibody|NIPP1 antibody|Nuclear inhibitor of protein phosphatase 1 antibody|nuclear inhibitor of protein phosphatase-1 alpha antibody|Nuclear subunit of PP1 antibody|PP1R8_HUMAN antibody|PPP1R8 antibody|PRO2047 antibody|Protein phosphatase 1 regulatory inhibitor subunit 8 antibody|Protein phosphatase 1 regulatory subunit 8 antibody|RNase E antibody|RNase E, E. coli, homolog of antibody
Anti-NIPP1 antibody (ab129286)
Close sc-136425|sc-393991|sc-271749|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-PPP1R8 Antibody

Catalogue No.

CSB-PA618641DSR2HU

Reactivity

Human

Immunogen

Recombinant human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:282319( Cow), Entrez Gene:5511( Human), Entrez Gene:100336( Mouse), Entrez Gene:313030( Rat), Omim:602636( Human), SwissProt:Q28147( Cow), SwissProt:Q12972( Human), SwissProt:Q8R3G1( Mouse), Unigene:533474( Human), Unigene:105230( Mouse), Unigene:16580( Rat)

Protein function

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3′ to purines and pyrimidines in A+U-rich regions. It generates 5′-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Protein tissue specificity

Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. .

Protein sequence and domain

Has a basic N- and C-terminal and an acidic central domain.; The FHA domain mediates interactions with threonine-phosphorylated MELK.

Protein post-translational modifications

May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA. .

Protein cellular localization

Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.

Research area

All research areas>Transcription Regulators>NIPP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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