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Rabbit Anti-PRKCE Antibody (CSB-PA018704ESR2HU)
Supplier: CUSABIO BIOTECH CO.
nPKC-epsilon Antibody,PRKCE Antibody,PKCE AntibodyMore alternative names for the antibody
KPCA_HUMAN antibody|PKC alpha antibody|PKC beta antibody|PKC delta antibody|PKC epsilon antibody|PKC gamma antibody|PKC zeta antibody|PKC-A antibody|PKC-alpha antibody|PKC2 antibody|PKCA antibody|PKCB antibody|PKCD antibody|PKCE antibody|PKCG antibody|PRKCA antibody|PRKCB antibody|PRKCD antibody|PRKCE antibody|PRKCG antibody|PRKCZ antibody|Protein kinase C alpha antibody|Protein kinase C alpha type antibody|Protein kinase C beta antibody|Protein kinase C delta antibody|Protein kinase C epsilon antibody|Protein kinase C gamma antibody|Protein kinase C zeta antibody
Anti-PKC antibody [MC5] (ab31)
Anti-PKC antibody [MC5] (ab31)
Recommended applications: ELISA, IP
Recommended dilution: Recommended dilution:IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein kinase C epsilon type protein (488-737AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5578( Human), Entrez Gene:5579( Human), Entrez Gene:5580( Human), Entrez Gene:5581( Human), Entrez Gene:5582( Human), Entrez Gene:5590( Human), Entrez Gene:18750( Mouse), Entrez Gene:18751( Mouse), Entrez Gene:18752( Mouse), Entrez Gene:18753( Mouse), Entrez Gene:18754( Mouse), Entrez Gene:18762( Mouse), Entrez Gene:170538( Rat), Entrez Gene:24680( Rat), Entrez Gene:24681( Rat), Entrez Gene:25023( Rat), Entrez Gene:25522( Rat), Entrez Gene:29340( Rat), Omim:176970( Human), Omim:176982( Human), SwissProt:P05129( Human), SwissProt:P05771( Human), SwissProt:P17252( Human), SwissProt:Q02156( Human), SwissProt:Q05513( Human), SwissProt:Q05655( Human), SwissProt:P20444( Mouse), SwissProt:P23298( Mouse), SwissProt:P63318( Mouse), SwissProt:P68404( Mouse), SwissProt:Q02956( Mouse), SwissProt:P05696( Rat), SwissProt:P09217( Rat), SwissProt:P63319( Rat), SwissProt:P68403( Rat), Unigene:460355( Human), Unigene:531704( Human), Unigene:708867( Human), Unigene:207496( Mouse), Unigene:222178( Mouse), Unigene:86669( Rat), Unigene:91118( Rat)
|Protein function|| |
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
|Protein post-translational modifications|| |
Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB. .
|Protein cellular localization|| |
Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cytoplasm, perinuclear region . Nucleus . Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). .
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|Product type|| |
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