Anti-PRMT1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PRMT1 Antibody (CSB-PA859113ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Histone-arginine N-methyltransferase PRMT1 Antibody,Interferon receptor 1-bound protein 4 Antibody,PRMT1 Antibody,HMT2 Antibody, HRMT1L2 Antibody, IR1B4 Antibody

More alternative names for the antibody
ANM 1 antibody|ANM1 antibody|ANM1_HUMAN antibody|HCP 1 antibody|HCP1 antibody|Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody|Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody|Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody|Histone-arginine N-methyltransferase PRMT1 antibody|HMT 2 antibody|HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody|HMT1 hnRNP methyltransferase antibody|HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody|HMT1 hnRNP methyltransferase like 2 antibody|HMT2 antibody|HRMT1 L2 antibody|HRMT1L 2 antibody|HRMT1L2 antibody|Human mRNA for suppressor for yeast mutant antibody|Human mRNA for suppressor for yeast mutant complete cds antibody|Interferon receptor 1 bound protein 4 antibody|Interferon receptor 1 bound protein4 antibody|Interferon receptor 1-bound protein 4 antibody|Interferon receptor 1bound protein 4 antibody|IR1 B4 antibody|IR1B 4 antibody|IR1B4 antibody|Mrmt 1 antibody|Mrmt1 antibody|PRMT 1 antibody|PRMT1 antibody|Protein arginine methyltransferase 1 antibody|Protein arginine N methyltransferase 1 antibody|Protein arginine N methyltransferase1 antibody|Protein arginine N-methyltransferase 1 antibody|R1B4 antibody|S. cerevisiae like 2 antibody
Anti-PRMT1 antibody (ab73246)
Close sc-166963|sc-13393|sc-271404|sc-30119|sc-59648|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PRMT1 Antibody

Catalogue No.

CSB-PA859113ESR2HU

Reactivity

Human

Immunogen

Recombinant human Protein arginine N-methyltransferase 1 protein (20-353AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

41 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:520388( Cow), Entrez Gene:3276( Human), Entrez Gene:15469( Mouse), Entrez Gene:60421( Rat), Omim:602950( Human), SwissProt:Q99873( Human), SwissProt:Q9JIF0( Mouse), SwissProt:Q63009( Rat), Unigene:20521( Human), Unigene:27545( Mouse), Unigene:5870( Rat)

Protein function

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 ‘Arg-4’ (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). .

Protein tissue specificity

Widely expressed. .

Protein sequence and domain

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

Protein cellular localization

Nucleus . Nucleus, nucleoplasm . Cytoplasm, cytosol . Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). .

Research area

All research areas>Signaling Intermediates>PRMT
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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