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Rabbit Anti-PRMT1 Antibody (CSB-PA859113ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Histone-arginine N-methyltransferase PRMT1 Antibody,Interferon receptor 1-bound protein 4 Antibody,PRMT1 Antibody,HMT2 Antibody, HRMT1L2 Antibody, IR1B4 AntibodyMore alternative names for the antibody
ANM 1 antibody|ANM1 antibody|ANM1_HUMAN antibody|HCP 1 antibody|HCP1 antibody|Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody|Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody|Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody|Histone-arginine N-methyltransferase PRMT1 antibody|HMT 2 antibody|HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody|HMT1 hnRNP methyltransferase antibody|HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody|HMT1 hnRNP methyltransferase like 2 antibody|HMT2 antibody|HRMT1 L2 antibody|HRMT1L 2 antibody|HRMT1L2 antibody|Human mRNA for suppressor for yeast mutant antibody|Human mRNA for suppressor for yeast mutant complete cds antibody|Interferon receptor 1 bound protein 4 antibody|Interferon receptor 1 bound protein4 antibody|Interferon receptor 1-bound protein 4 antibody|Interferon receptor 1bound protein 4 antibody|IR1 B4 antibody|IR1B 4 antibody|IR1B4 antibody|Mrmt 1 antibody|Mrmt1 antibody|PRMT 1 antibody|PRMT1 antibody|Protein arginine methyltransferase 1 antibody|Protein arginine N methyltransferase 1 antibody|Protein arginine N methyltransferase1 antibody|Protein arginine N-methyltransferase 1 antibody|R1B4 antibody|S. cerevisiae like 2 antibody
Anti-PRMT1 antibody (ab73246)
Anti-PRMT1 antibody (ab73246)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein arginine N-methyltransferase 1 protein (20-353AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:520388( Cow), Entrez Gene:3276( Human), Entrez Gene:15469( Mouse), Entrez Gene:60421( Rat), Omim:602950( Human), SwissProt:Q99873( Human), SwissProt:Q9JIF0( Mouse), SwissProt:Q63009( Rat), Unigene:20521( Human), Unigene:27545( Mouse), Unigene:5870( Rat)
|Protein function|| |
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 ‘Arg-4’ (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). .
|Protein tissue specificity|| |
Widely expressed. .
|Protein sequence and domain|| |
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
|Protein cellular localization|| |
Nucleus . Nucleus, nucleoplasm . Cytoplasm, cytosol . Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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