Anti-PTPN1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PTPN1 Antibody (CSB-PA019024DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein-tyrosine phosphatase 1B Antibody,PTP-1B Antibody,PTPN1 Antibody,PTP1B Antibody

More alternative names for the antibody
PTP1B antibody|Non receptor tyrosine phosphatase 1 antibody|Protein phosphotyrosylphosphatase 1B antibody|Protein tyrosine phosphatase 1B antibody|Protein tyrosine phosphatase non receptor type 1 antibody|Protein tyrosine phosphatase placental antibody|Protein-tyrosine phosphatase 1B antibody|PTN1_HUMAN antibody|PTP 1B antibody|PTP-1B antibody|PTPN 1 antibody|PTPN1 antibody|Tyrosine protein phosphatase non receptor type 1 antibody|Tyrosine-protein phosphatase non-receptor type 1 antibody
Anti-PTP1B antibody [4F8F11] (ab201974)
Close sc-56960|sc-133115|sc-1719|sc-133259|sc-14021|sc-133258|sc-1718|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-PTPN1 Antibody

Catalogue No.

CSB-PA019024DSR1HU

Reactivity

Human

Immunogen

Recombinant human Tyrosine-protein phosphatase non-receptor type 1 protein (281-435AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

49 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:395688( Chicken), Entrez Gene:5770( Human), Entrez Gene:19246( Mouse), Entrez Gene:24697( Rat), Omim:176885( Human), SwissProt:O13016( Chicken), SwissProt:P18031( Human), SwissProt:P35821( Mouse), SwissProt:P20417( Rat), Unigene:417549( Human), Unigene:277916( Mouse), Unigene:11317( Rat)

Protein function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. .

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

Protein post-translational modifications

Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. .; Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. .; S-nitrosylation of Cys-215 inactivates the enzyme activity. .; Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.

Protein cellular localization

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Interacts with EPHA3 at the cell membrane.

Research area

All research areas>Kinases and Phosphatases>PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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