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Rabbit Anti-PTPRB Antibody (CSB-PA019048ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Receptor-type tyrosine-protein phosphatase beta Antibody,Protein-tyrosine phosphatase beta Antibody,R-PTP-beta Antibody,Vascular endothelial protein tyrosine phosphatase Antibody,VE-PTP Antibody,PTPRB Antibody,PTPB AntibodyMore alternative names for the antibody
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Receptor-type tyrosine-protein phosphatase beta protein (1758-1997AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). .
|Protein sequence and domain|| |
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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