Anti-PTPRE Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PTPRE Antibody (CSB-PA019052ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Receptor-type tyrosine-protein phosphatase epsilon Antibody,Protein-tyrosine phosphatase epsilon Antibody,R-PTP-epsilon Antibody,PTPRE Antibody

More alternative names for the antibody
DKFZp313F1310 antibody|FLJ57799 antibody|FLJ58245 antibody|HPTPE antibody|Protein tyrosine phosphatase epsilon antibody|Protein tyrosine phosphatase receptor type E antibody|Protein tyrosine phosphatase receptor type epsilon antibody|Protein tyrosine phosphatase receptor type epsilon polypeptide antibody|Protein-tyrosine phosphatase epsilon antibody|PTPE antibody|Ptpre antibody|PTPRE_HUMAN antibody|R PTP Epsilon antibody|R-PTP-epsilon antibody|Receptor-type tyrosine-protein phosphatase epsilon antibody
Anti-PTP epsilon antibody [EPR6715] (ab126788)
Close sc-1117|sc-367762|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PTPRE Antibody

Catalogue No.

CSB-PA019052ESR2HU

Reactivity

Human

Immunogen

Recombinant human Receptor-type tyrosine-protein phosphatase epsilon protein (20-200AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

80 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5791( Human), Entrez Gene:19267( Mouse), Entrez Gene:114767( Rat), Omim:600926( Human), SwissProt:P23469( Human), SwissProt:P49446( Mouse), SwissProt:B2GV87( Rat), Unigene:127022( Human), Unigene:945( Mouse), Unigene:107819( Rat)

Protein function

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). .; Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). .; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). .

Protein tissue specificity

Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). .

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).

Protein post-translational modifications

A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3. .; Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu. .; Isoform 1 is glycosylated. .

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). .; Isoform 3: Cytoplasm.

Research area

All research areas>Kinases and Phosphatases>PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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