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Rabbit Anti-RAB31 Antibody (CSB-PA614438ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Ras-related protein Rab-31 Antibody,Ras-related protein Rab-22B Antibody,RAB31 Antibody,RAB22B AntibodyMore alternative names for the antibody
Rab 22B antibody|
Anti-RAB31 antibody (ab89163)
Anti-RAB31 antibody (ab89163)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ras-related protein Rab-31 protein (1-195AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11031" target="_blank">Entrez Gene:11031( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/605694" target="_blank">Omim:605694( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q13636" target="_blank">SwissProt:Q13636( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=727531" target="_blank">Unigene:727531( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=99528" target="_blank">Unigene:99528( Human)</a>
|Protein function|| |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. .
|Protein tissue specificity|| |
Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. .
|Protein sequence and domain|| |
Belongs to the small GTPase superfamily. Rab family.
|Protein cellular localization|| |
Golgi apparatus, trans-Golgi network . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). .
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CUSABIO BIOTECH CO.
|Product type|| |
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