Anti-RAB5A Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RAB5A Antibody (CSB-PA019213ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

RAB5A Antibody,RAB5 Antibody

More alternative names for the antibody
RAB 5 antibody|
Anti-Rab5 antibody – Early Endosome Marker (ab18211)
Close sc-46692|sc-28570|sc-130010|sc-166622|sc-166601|sc-166600|sc-26566|sc-309|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RAB5A Antibody

Catalogue No.

CSB-PA019213ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Ras-related protein Rab-5A protein (1-215AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

23 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5868( Human), Entrez Gene:271457( Mouse), Entrez Gene:64633( Rat), Omim:179512( Human), SwissProt:P20339( Human), SwissProt:Q9CQD1( Mouse), SwissProt:M0RC99( Rat), Unigene:475663( Human), Unigene:329123( Mouse), Unigene:44477( Rat)

Protein function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). .

Protein sequence and domain

Belongs to the small GTPase superfamily. Rab family.

Protein cellular localization

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome membrane ; Lipid-anchor . Melanosome . Cytoplasmic vesicle . Cell projection, ruffle . Membrane . Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane . Endosome membrane . Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable). .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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