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Rabbit Anti-RACGAP1 Antibody (CSB-PA884432DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Rac GTPase-activating protein 1 Antibody,Male germ cell RacGap Antibody,MgcRacGAP Antibody,Protein CYK4 homolog Antibody,CYK4 Antibody,HsCYK-4 Antibody,RACGAP1 AntibodyMore alternative names for the antibody
CYK4 antibody|GAP antibody|Gap1 antibody|GTPase activating protein antibody|HsCYK-4 antibody|ID GAP antibody|KIAA1478 antibody|Male germ cell RacGap antibody|MgcRacGAP antibody|Protein CYK4 homolg antibody|Protein CYK4 homolog antibody|Rac GTPase activating protein 1 antibody|Rac GTPase-activating protein 1 antibody|RACGAP 1 antibody|Racgap1 antibody|RGAP1_HUMAN antibody
Anti-RACGAP1 antibody (ab2270)
Anti-RACGAP1 antibody (ab2270)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Rac GTPase-activating protein 1 protein (353-632AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29127" target="_blank">Entrez Gene:29127( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/604980" target="_blank">Omim:604980( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9H0H5" target="_blank">SwissProt:Q9H0H5( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=505469" target="_blank">Unigene:505469( Human)</a>
|Protein function|| |
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. .
|Protein tissue specificity|| |
Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase. .
|Protein sequence and domain|| |
The coiled coil region is indispensible for localization to the midbody during cytokinesis.; The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in phosphatidylinositol 3,4,5-trisphosphate and is required during mitotic cytokinesis for normal attachment of the midbody to the cell membrane.
|Protein post-translational modifications|| |
Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-387 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation. .
|Protein cellular localization|| |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. .
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CUSABIO BIOTECH CO.
|Product type|| |
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