Anti-RDH12 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RDH12 Antibody (CSB-PA842727ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Retinol dehydrogenase 12 Antibody,All-trans and 9-cis retinol dehydrogenase Antibody,Short chain dehydrogenase/reductase family 7C member 2 Antibody,RDH12 Antibody,SDR7C2 Antibody

More alternative names for the antibody
All trans and 9 cis retinol dehydrogenase antibody|All-trans and 9-cis retinol dehydrogenase antibody|LCA 3 antibody|LCA13 antibody|LCA3 antibody|RDH 12 antibody|RDH12 antibody|RDH12_HUMAN antibody|Retinol dehydrogenase 12 (all trans/9 cis/11 cis) antibody|Retinol dehydrogenase 12 all trans and 9 cis antibody|Retinol dehydrogenase 12 antibody|RP53 antibody|SDR7C2 antibody|Short chain dehydrogenase/reductase family 7C member 2 antibody
Anti-RDH12 antibody (ab173449)
Close sc-79019|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RDH12 Antibody

Catalogue No.

CSB-PA842727ESR1HU

Reactivity

Human

Immunogen

Recombinant human Retinol dehydrogenase 12 protein (182-316AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

35 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:369021( Cow), Entrez Gene:145226( Human), Omim:608830( Human), SwissProt:P59837( Cow), SwissProt:Q96NR8( Human), Unigene:415322( Human)

Protein function

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. .

Protein tissue specificity

Widely expressed, mostly in eye, kidney, brain, skeletal muscle and stomach.

Involvement in disease

Leber congenital amaurosis 13 (LCA13) [MIM:612712]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Retinitis pigmentosa 53 (RP53) [MIM:612712]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Research area

All research areas>Synthesis and Degradation>RDH
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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