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Rabbit Anti-RFFL Antibody (CSB-PA848846DSR2HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase rififylinCurated Antibody,Caspase regulator CARP2 Antibody,Caspases-8 and -10-associated RING finger protein 2 Antibody,CARP-2 Antibody,FYVE-RING finger protein Sakura Antibody,Fring Antibody,RING finger and FYVE-like domain-containing protein 1 Antibody,RING finger protein 189 Antibody,RING finger protein 34-like Antibody,RFFL AntibodyMore alternative names for the antibody
CARP-2 antibody|CARP2 antibody|Caspase regulator CARP2 antibody|Caspases 8 and 10 associated RING finger protein 2 antibody|caspases-8 and -10- associated RING finger protein 2 antibody|Caspases-8 and -10-associated RING finger protein 2 antibody|E3 ubiquitin protein ligase rififylin antibody|E3 ubiquitin-protein ligase rififylin antibody|Fring antibody|FYVE RING finger protein Sakura antibody|FYVE-RING finger protein Sakura antibody|Rffl antibody|RFFL_HUMAN antibody|Rififylin antibody|RING finger and FYVE like domain containing protein antibody|RING finger and FYVE-like domain-containing protein 1 antibody|RING finger protein 189 antibody|RING finger protein 34 like antibody|RING finger protein 34-like antibody|RNF189 antibody|RNF34L antibody
Anti-Rffl antibody (ab47994)
Anti-Rffl antibody (ab47994)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase rififylin protein (1-190AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:530263( Cow), Entrez Gene:117584( Human), Entrez Gene:67338( Mouse), Entrez Gene:282844( Rat), Omim:609735( Human), SwissProt:Q8WZ73( Human), SwissProt:Q6ZQM0( Mouse), SwissProt:Q8CIN9( Rat), Unigene:13680( Human), Unigene:341608( Mouse), Unigene:159718( Rat)
|Protein function|| |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates ‘Lys-48’-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. .
|Protein tissue specificity|| |
Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. .
|Protein sequence and domain|| |
The RING-type zinc finger is required for the ubiquitination of target proteins.; The FYVE-type zinc finger domain is required for localization to the recycling endosome membranes and the function in endocytic recycling.
|Protein post-translational modifications|| |
Autoubiquitinated. .; Palmitoylated. .; Undergoes caspase-mediated cleavage upon death-receptor activation, by TNFSF10 for instance. May be mediated by the caspases CASP8 and CASP10 in a negative feedback loop.
|Protein cellular localization|| |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane ; Peripheral membrane protein . Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
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CUSABIO BIOTECH CO.
|Product type|| |
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