Anti-RFX5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RFX5 Antibody (CSB-PA019614ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Regulatory factor X 5 Antibody,RFX5 Antibody

More alternative names for the antibody
DNA binding protein RFX 5 antibody|DNA binding protein RFX5 antibody|DNA-binding protein RFX5 antibody|Influences HLA class II expression antibody|Regulatory factor X 5 antibody|Regulatory factor X subunit 5 antibody|Regulatory factor X, 5 (influences HLA class II expression) antibody|RFX 5 antibody|RFX5 antibody|Rfx5 protein antibody|RFX5_HUMAN antibody
Anti-RFX5 antibody (ab9255)
Close sc-271757|sc-10666|sc-271756|sc-10667|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RFX5 Antibody

Catalogue No.

CSB-PA019614ESR2HU

Reactivity

Human

Immunogen

Recombinant human DNA-binding protein RFX5 protein (367-616AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

65 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5993( Human), Omim:601863( Human), SwissProt:P48382( Human), Unigene:632472( Human)

Protein function

Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.

Protein tissue specificity

Ubiquitous.

Involvement in disease

Bare lymphocyte syndrome 2 (BLS2) [MIM:209920]: A severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the RFX family. The N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.; The PxLPxI/L motif mediates interaction with ankyrin repeats of RFXANK.

Protein post-translational modifications

Phosphorylated.

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>RFX
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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