Anti-RICTOR Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RICTOR Antibody (CSB-PA761396ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

AVO3 homolog Antibody,hAVO3 Antibody,RICTOR Antibody

More alternative names for the antibody
AVO3 antibody|AVO3 homolog antibody|DKFZp686B11164 antibody|hAVO3 antibody|KIAA1999 antibody|Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody|mAVO3 antibody|MGC39830 antibody|PIA antibody|Pianissimo antibody|Rapamycin insensitive companion of mTOR antibody|Rapamycin-insensitive companion of mTOR antibody|Rictor antibody|RICTR antibody|RICTR_HUMAN antibody|RPTOR independent companion of MTOR complex 2 antibody|TORC2 specific protein AVO3 antibody
Anti-RICTOR antibody (ab70374)
Close sc-81538|sc-271081|sc-99004|sc-50678|sc-130865|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RICTOR Antibody

Catalogue No.

CSB-PA761396ESR1HU

Reactivity

Human

Immunogen

Recombinant human Rapamycin-insensitive companion of mTOR protein (1-245AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

192 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:461907( Chimpanzee), Entrez Gene:479356( Dog), Entrez Gene:101132782( Gorilla), Entrez Gene:253260( Human), Entrez Gene:78757( Mouse), Entrez Gene:100443248( Orangutan), Entrez Gene:694915( Rhesus monkey), Omim:609022( Human), SwissProt:Q6R327( Human), SwissProt:Q6QI06( Mouse), Unigene:407926( Human), Unigene:275811( Mouse)

Protein function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ‘Ser-473’ phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on ‘Thr-308’ by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at ‘Ser-422’. mTORC2 also modulates the phosphorylation of PRKCA on ‘Ser-657’. Plays an essential role in embryonic growth and development. .

Protein sequence and domain

Belongs to the RICTOR family.

Protein post-translational modifications

Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling. .

Research area

All research areas>Signaling Intermediates>Rictor
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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