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Rabbit Anti-RIPK2 Antibody (CSB-PA019736ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Receptor-interacting serine/threonine-protein kinase 2 Antibody,CARD-containing interleukin-1 beta-converting enzyme-associated kinase Antibody,CARD-containing IL-1 beta ICE-kinase Antibody,RIP-like-interacting CLARP kinase Antibody,Receptor-interacting protein 2 Antibody, RIP-2 Antibody,Tyrosine-protein kinase RIPK2 Antibody,RIPK2 Antibody,CARDIAK Antibody, RICK Antibody,RIP2 AntibodyMore alternative names for the antibody
CARD 3 antibody|CARD carrying kinase antibody|CARD containing ICE associated kinase antibody|CARD containing IL 1 beta ICE kinase antibody|CARD containing IL1 beta ICE kinase antibody|CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody|CARD containing interleukin 1 beta converting enzyme associated kinase antibody|CARD-containing IL-1 beta ICE-kinase antibody|CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody|CARD3 antibody|CARDIAK antibody|CCK antibody|CLARP kinase antibody|GIG 30 antibody|GIG30 antibody|Growth inhibiting gene 30 antibody|Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody|Receptor interacting protein 2 antibody|Receptor interacting serine threonine kinase 2 antibody|Receptor interacting serine/threonine protein kinase 2 antibody|Receptor-interacting protein 2 antibody|Receptor-interacting serine/threonine-protein kinase 2 antibody|RICK antibody|RIP 2 antibody|RIP like interacting CLARP kinase antibody|RIP-2 antibody|RIP-like-interacting CLARP kinase antibody|RIPK 2 antibody|Ripk2 antibody|RIPK2_HUMAN antibody|TNFRSF antibody|Tyrosine-protein kinase RIPK2 antibody|UNQ277/PRO314/PRO34092 antibody
Anti-RIP2 antibody (ab8428)
Anti-RIP2 antibody (ab8428)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Receptor-interacting serine/threonine-protein kinase 2 protein (1-540AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:8767( Human), Entrez Gene:192656( Mouse), Entrez Gene:362491( Rat), Omim:603455( Human), SwissProt:O43353( Human), SwissProt:P58801( Mouse), Unigene:103755( Human), Unigene:112765( Mouse), Unigene:102179( Rat)
|Protein function|| |
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes ‘Lys-63’-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces ‘Lys-63’-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. .
|Protein tissue specificity|| |
Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins.
|Protein post-translational modifications|| |
Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation. .; Ubiquitinated on Lys-209; undergoes ‘Lys-63’-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with ‘Lys-48’ and ‘Lys-63’-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Also undergoes ‘Met-1’-linked polyubiquitination; the head-to-tail linear polyubiquitination is mediated by the LUBAC complex in response to NOD2 stimulation. Linear polyubiquitination is restricted by FAM105B/otulin, probably to limit NOD2-dependent proinflammatory signaling activation of NF-kappa-B. .
|Protein cellular localization|| |
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|Product type|| |
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