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Rabbit Anti-RIPK3 Antibody (CSB-PA897497ESR1HU)
Supplier: CUSABIO BIOTECH CO.
RIP-like protein kinase 3 Antibody,Receptor-interacting protein 3 Antibody,RIP-3 Antibody,RIPK3 Antibody,RIP3 AntibodyMore alternative names for the antibody
Receptor interacting protein 3 antibody|Receptor interacting serine threonine kinase 3 antibody|Receptor interacting serine/threonine protein kinase 3 antibody|Receptor-interacting protein 3 antibody|Receptor-interacting serine/threonine-protein kinase 3 antibody|RIP 3 antibody|RIP like protein kinase 3 antibody|RIP-3 antibody|RIP-like protein kinase 3 antibody|RIPK 3 antibody|RIPK3 antibody|RIPK3_HUMAN antibody
Anti-RIP3 antibody (ab56164)
Anti-RIP3 antibody (ab56164)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Receptor-interacting serine/threonine-protein kinase 3 protein (1-120AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:11035( Human), Entrez Gene:56532( Mouse), Entrez Gene:246240( Rat), Omim:605817( Human), SwissProt:Q9Y572( Human), SwissProt:Q9QZL0( Mouse), SwissProt:Q9Z2P5( Rat), Unigene:268551( Human), Unigene:46612( Mouse), Unigene:7110( Rat)
|Protein function|| |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. .
|Protein tissue specificity|| |
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
|Protein post-translational modifications|| |
RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL. .; Polyubiquitinated with ‘Lys-48’ and ‘Lys-63’-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. .
|Protein cellular localization|| |
Cytoplasm, cytosol . Cell membrane . Mitochondrion .
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|Product type|| |
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