Anti-RIPK3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RIPK3 Antibody (CSB-PA897497ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

RIP-like protein kinase 3 Antibody,Receptor-interacting protein 3 Antibody,RIP-3 Antibody,RIPK3 Antibody,RIP3 Antibody

More alternative names for the antibody
Receptor interacting protein 3 antibody|Receptor interacting serine threonine kinase 3 antibody|Receptor interacting serine/threonine protein kinase 3 antibody|Receptor-interacting protein 3 antibody|Receptor-interacting serine/threonine-protein kinase 3 antibody|RIP 3 antibody|RIP like protein kinase 3 antibody|RIP-3 antibody|RIP-like protein kinase 3 antibody|RIPK 3 antibody|RIPK3 antibody|RIPK3_HUMAN antibody
Anti-RIP3 antibody (ab56164)
Close sc-47364|sc-47366|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RIPK3 Antibody

Catalogue No.

CSB-PA897497ESR1HU

Reactivity

Human

Immunogen

Recombinant human Receptor-interacting serine/threonine-protein kinase 3 protein (1-120AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

56 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:11035( Human), Entrez Gene:56532( Mouse), Entrez Gene:246240( Rat), Omim:605817( Human), SwissProt:Q9Y572( Human), SwissProt:Q9QZL0( Mouse), SwissProt:Q9Z2P5( Rat), Unigene:268551( Human), Unigene:46612( Mouse), Unigene:7110( Rat)

Protein function

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. .

Protein tissue specificity

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. .

Protein sequence and domain

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Protein post-translational modifications

RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL. .; Polyubiquitinated with ‘Lys-48’ and ‘Lys-63’-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. .

Protein cellular localization

Cytoplasm, cytosol . Cell membrane . Mitochondrion .

Research area

All research areas>Kinases and Phosphatases>RIP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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