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Rabbit Anti-RNF11 Antibody (CSB-PA019816ESR2HU)
Supplier: CUSABIO BIOTECH CO.
RING finger protein 11 Antibody,RNF11 Antibody,CGI-123 AntibodyMore alternative names for the antibody
CGI 123 antibody|RING finger protein 11 antibody|RNF11 antibody|RNF11_HUMAN antibody|Sid 1669 antibody|SID1669 antibody
Anti-RNF11 antibody [EPR6820] (ab154831)
Anti-RNF11 antibody [EPR6820] (ab154831)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human RING finger protein 11 protein (1-154AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26994" target="_blank">Entrez Gene:26994( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/612598" target="_blank">Omim:612598( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9Y3C5" target="_blank">SwissProt:Q9Y3C5( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=309641" target="_blank">Unigene:309641( Human)</a>
|Protein function|| |
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. .
|Protein tissue specificity|| |
Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines. .
|Protein sequence and domain|| |
The WW-binding motif mediates interaction with NEDD4.
|Protein post-translational modifications|| |
Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1. .; Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome. .; Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes. .
|Protein cellular localization|| |
Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. .
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="https://antibodyplus.com/product-tag/RNF/">RNF</a><br><a href="https://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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|Product type|| |
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