Anti-RNF125 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RNF125 Antibody (CSB-PA836205ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

RING finger protein 125 Antibody,T-cell RING activation protein 1 Antibody,TRAC-1 Antibody

More alternative names for the antibody
E3 ubiquitin protein ligase RNF125 antibody|Ring finger protein 125 antibody|RNF 125 antibody|T cell RING activation protein 1 antibody|T cell ring protein identified in activation screen antibody|TRAC 1 antibody
Anti-RNF125 antibody (ab74373)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RNF125 Antibody

Catalogue No.

CSB-PA836205ESR2HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase RNF125 protein (1-232AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

26 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:54941( Human), Entrez Gene:67664( Mouse), Entrez Gene:361296( Rat), Omim:610432( Human), SwissProt:Q96EQ8( Human), SwissProt:Q9D9R0( Mouse), Unigene:633703( Human), Unigene:45980( Mouse), Unigene:163367( Rat)

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at ‘Lys-181’, leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). .

Protein tissue specificity

Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. .

Involvement in disease

Tenorio syndrome (TNORS) [MIM:616260]: A disease characterized by overgrowth, macrocephaly, and intellectual disability. Some patients may have mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sjogren syndrome. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The C2HC RNF-type zinc finger and the linker region stabilize the RING-type zinc finger, leading to promote binding of the RING-type zinc finger to the ubiquitin-conjugating enzyme E2 (donor ubiquitin) (PubMed:27411375).

Protein post-translational modifications

Autoubiquitinated, leading to its subsequent proteasomal degradation. .

Protein cellular localization

Golgi apparatus membrane ; Lipid-anchor . Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. .

Research area

All research areas>Transcription Regulators>TRAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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