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Rabbit Anti-RNF125 Antibody (CSB-PA836205ESR2HU)
Supplier: CUSABIO BIOTECH CO.
RING finger protein 125 Antibody,T-cell RING activation protein 1 Antibody,TRAC-1 AntibodyMore alternative names for the antibody
E3 ubiquitin protein ligase RNF125 antibody|Ring finger protein 125 antibody|RNF 125 antibody|T cell RING activation protein 1 antibody|T cell ring protein identified in activation screen antibody|TRAC 1 antibody
Anti-RNF125 antibody (ab74373)
Anti-RNF125 antibody (ab74373)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase RNF125 protein (1-232AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:54941( Human), Entrez Gene:67664( Mouse), Entrez Gene:361296( Rat), Omim:610432( Human), SwissProt:Q96EQ8( Human), SwissProt:Q9D9R0( Mouse), Unigene:633703( Human), Unigene:45980( Mouse), Unigene:163367( Rat)
|Protein function|| |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at ‘Lys-181’, leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). .
|Protein tissue specificity|| |
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. .
|Involvement in disease|| |
Tenorio syndrome (TNORS) [MIM:616260]: A disease characterized by overgrowth, macrocephaly, and intellectual disability. Some patients may have mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sjogren syndrome. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The C2HC RNF-type zinc finger and the linker region stabilize the RING-type zinc finger, leading to promote binding of the RING-type zinc finger to the ubiquitin-conjugating enzyme E2 (donor ubiquitin) (PubMed:27411375).
|Protein post-translational modifications|| |
Autoubiquitinated, leading to its subsequent proteasomal degradation. .
|Protein cellular localization|| |
Golgi apparatus membrane ; Lipid-anchor . Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. .
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CUSABIO BIOTECH CO.
|Product type|| |
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