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Rabbit Anti-RNF139 Antibody (CSB-PA837849DSR2HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase RNF139 Antibody,RING finger protein 139 Antibody,Translocation in renal carcinoma on chromosome 8 protein Antibody,RNF139 AntibodyMore alternative names for the antibody
E3 ubiquitin-protein ligase RNF139 antibody|HRCA1 antibody|RCA1 antibody|Ring finger protein 139 antibody|Translocation in renal carcinoma on chromosome 8 protein antibody|TRC8 antibody
Anti-RNF139 antibody (ab56924)
Anti-RNF139 antibody (ab56924)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase RNF139 protein (510-664AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. .
|Protein tissue specificity|| |
Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney. .
|Involvement in disease|| |
Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1) with FHIT. RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained and expressed. Sporadic cases of renal carcinoma, where an acquired mutation in RNF139 results in the duplication of 12 nucleotides in the 5′-UTR, has also been identified.
|Protein sequence and domain|| |
The RING-type zinc finger domain mediates ubiquitin ligase activity.
|Protein post-translational modifications|| |
Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome pathway. .
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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