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Rabbit Anti-RNF34 Antibody (CSB-PA856886ESR2HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase RNF34Curated Antibody,Caspase regulator CARP1Curated Antibody,Caspases-8 and -10-associated RING finger protein 1 Antibody,RNF34 AntibodyMore alternative names for the antibody
CARP 1 antibody|CARP-1 antibody|CARP1 antibody|Caspase regulator CARP1 antibody|Caspases-8 and -10-associated RING finger protein 1 antibody|E3 ubiquitin-protein ligase RNF34 antibody|FYVE-RING finger protein Momo antibody|hRFI antibody|Human RING finger homologous to inhibitor of apoptosis protein antibody|RFI antibody|RIF antibody|RIFF antibody|RING finger protein 34 antibody|RING finger protein RIFF antibody|RNF34 antibody|RNF34_HUMAN antibody
Anti-RNF34 antibody (ab117084)
Anti-RNF34 antibody (ab117084)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:506764( Cow), Entrez Gene:477470( Dog), Entrez Gene:80196( Human), Entrez Gene:80751( Mouse), Entrez Gene:282845( Rat), Omim:608299( Human), SwissProt:Q5E9J6( Cow), SwissProt:Q969K3( Human), SwissProt:Q99KR6( Mouse), SwissProt:Q6AYH3( Rat), Unigene:292804( Human), Unigene:388529( Mouse), Unigene:14904( Rat)
|Protein function|| |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate ‘Lys-48’-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through ‘Lys-48’-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). .
|Protein tissue specificity|| |
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. .
|Protein sequence and domain|| |
The RING-type zinc finger is required for the ubiquitination of target proteins.; The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids.
|Protein post-translational modifications|| |
Autoubiquitinated (in vitro). .; Proteolytically cleaved by caspases upon induction of apoptosis by TNF. .
|Protein cellular localization|| |
Cell membrane ; Peripheral membrane protein . Endomembrane system ; Peripheral membrane protein . Nucleus . Nucleus speckle . Cytoplasm, cytosol .
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CUSABIO BIOTECH CO.
|Product type|| |
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