Anti-RNF34 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RNF34 Antibody (CSB-PA856886ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase RNF34Curated Antibody,Caspase regulator CARP1Curated Antibody,Caspases-8 and -10-associated RING finger protein 1 Antibody,RNF34 Antibody

More alternative names for the antibody
CARP 1 antibody|CARP-1 antibody|CARP1 antibody|Caspase regulator CARP1 antibody|Caspases-8 and -10-associated RING finger protein 1 antibody|E3 ubiquitin-protein ligase RNF34 antibody|FYVE-RING finger protein Momo antibody|hRFI antibody|Human RING finger homologous to inhibitor of apoptosis protein antibody|RFI antibody|RIF antibody|RIFF antibody|RING finger protein 34 antibody|RING finger protein RIFF antibody|RNF34 antibody|RNF34_HUMAN antibody
Anti-RNF34 antibody (ab117084)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RNF34 Antibody

Catalogue No.

CSB-PA856886ESR2HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

41 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:506764( Cow), Entrez Gene:477470( Dog), Entrez Gene:80196( Human), Entrez Gene:80751( Mouse), Entrez Gene:282845( Rat), Omim:608299( Human), SwissProt:Q5E9J6( Cow), SwissProt:Q969K3( Human), SwissProt:Q99KR6( Mouse), SwissProt:Q6AYH3( Rat), Unigene:292804( Human), Unigene:388529( Mouse), Unigene:14904( Rat)

Protein function

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate ‘Lys-48’-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through ‘Lys-48’-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). .

Protein tissue specificity

Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. .

Protein sequence and domain

The RING-type zinc finger is required for the ubiquitination of target proteins.; The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids.

Protein post-translational modifications

Autoubiquitinated (in vitro). .; Proteolytically cleaved by caspases upon induction of apoptosis by TNF. .

Protein cellular localization

Cell membrane ; Peripheral membrane protein . Endomembrane system ; Peripheral membrane protein . Nucleus . Nucleus speckle . Cytoplasm, cytosol .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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