Anti-RNF41 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RNF41 Antibody (CSB-PA880976ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase NRDP1 Antibody,RING finger protein 41 Antibody,RNF41 Antibody,FLRF Antibody,NRDP1 Antibody,SBBI03 Antibody

More alternative names for the antibody
4930511A05Rik antibody|4933415P08Rik antibody|E3 ubiquitin protein ligase NRDP1 antibody|E3 ubiquitin-protein ligase NRDP1 antibody|Fetal Liver RING finger protein antibody|FLRF antibody|MGC45228 antibody|Neuregulin receptor degradation protein 1 antibody|NRDP1 antibody|RING finger protein 41 antibody|rnf41 antibody|RNF41_HUMAN antibody|SBBI03 antibody
Anti-RNF41 antibody (ab151231)
Close sc-365622|sc-374120|sc-79996|sc-98353|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-RNF41 Antibody

Catalogue No.

CSB-PA880976ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

35 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10193( Human), Entrez Gene:67588( Mouse), Entrez Gene:362814( Rat), Entrez Gene:734308( Xenopus laevis), Entrez Gene:406837( Zebrafish), SwissProt:Q9H4P4( Human), SwissProt:Q8BH75( Mouse), SwissProt:Q5FWL3( Xenopus laevis), SwissProt:Q7ZW16( Zebrafish), Unigene:524502( Human), Unigene:294120( Mouse), Unigene:71609( Xenopus laevis), Unigene:78078( Zebrafish)

Protein function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). .

Protein tissue specificity

Detected in ovary, testis and prostate. .

Protein post-translational modifications

Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. .

Research area

All research areas>Synthesis and Degradation>Nrdp1
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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