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Rabbit Anti-RNF41 Antibody (CSB-PA880976ESR1HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase NRDP1 Antibody,RING finger protein 41 Antibody,RNF41 Antibody,FLRF Antibody,NRDP1 Antibody,SBBI03 AntibodyMore alternative names for the antibody
4930511A05Rik antibody|4933415P08Rik antibody|E3 ubiquitin protein ligase NRDP1 antibody|E3 ubiquitin-protein ligase NRDP1 antibody|Fetal Liver RING finger protein antibody|FLRF antibody|MGC45228 antibody|Neuregulin receptor degradation protein 1 antibody|NRDP1 antibody|RING finger protein 41 antibody|rnf41 antibody|RNF41_HUMAN antibody|SBBI03 antibody
Anti-RNF41 antibody (ab151231)
Anti-RNF41 antibody (ab151231)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:10193( Human), Entrez Gene:67588( Mouse), Entrez Gene:362814( Rat), Entrez Gene:734308( Xenopus laevis), Entrez Gene:406837( Zebrafish), SwissProt:Q9H4P4( Human), SwissProt:Q8BH75( Mouse), SwissProt:Q5FWL3( Xenopus laevis), SwissProt:Q7ZW16( Zebrafish), Unigene:524502( Human), Unigene:294120( Mouse), Unigene:71609( Xenopus laevis), Unigene:78078( Zebrafish)
|Protein function|| |
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). .
|Protein tissue specificity|| |
Detected in ovary, testis and prostate. .
|Protein post-translational modifications|| |
Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. .
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CUSABIO BIOTECH CO.
|Product type|| |
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