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Rabbit Anti-ROBO2 Antibody (CSB-PA888028ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Roundabout homolog 2 Antibody,ROBO2 Antibody,KIAA1568 AntibodyMore alternative names for the antibody
lea antibody|Robo 2 antibody|Robo2 antibody|ROBO2_HUMAN antibody|Roundabout 2 antibody|Roundabout homolog 2 antibody|roundabout, axon guidance receptor, homolog 2 (Drosophila) antibody|Roundabout2 antibody|SAX 3 antibody|SAX3 antibody
Anti-Robo2 antibody (ab75014)
Anti-Robo2 antibody (ab75014)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Roundabout homolog 2 protein (450-660AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
|Involvement in disease|| |
Vesicoureteral reflux 2 (VUR2) [MIM:610878]: A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
|Protein sequence and domain|| |
Belongs to the immunoglobulin superfamily. ROBO family.
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein .
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|Product type|| |
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