Anti-ROBO2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ROBO2 Antibody (CSB-PA888028ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Roundabout homolog 2 Antibody,ROBO2 Antibody,KIAA1568 Antibody

More alternative names for the antibody
lea antibody|Robo 2 antibody|Robo2 antibody|ROBO2_HUMAN antibody|Roundabout 2 antibody|Roundabout homolog 2 antibody|roundabout, axon guidance receptor, homolog 2 (Drosophila) antibody|Roundabout2 antibody|SAX 3 antibody|SAX3 antibody
Anti-Robo2 antibody (ab75014)
Close sc-376177|sc-16615|sc-25673|sc-31607|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ROBO2 Antibody

Catalogue No.

CSB-PA888028ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Roundabout homolog 2 protein (450-660AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

151 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6092( Human), Entrez Gene:268902( Mouse), Entrez Gene:84409( Rat), Omim:602431( Human), SwissProt:Q9HCK4( Human), SwissProt:Q7TPD3( Mouse), Unigene:13305( Human), Unigene:171736( Mouse)

Protein function

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

Involvement in disease

Vesicoureteral reflux 2 (VUR2) [MIM:610878]: A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.

Protein sequence and domain

Belongs to the immunoglobulin superfamily. ROBO family.

Protein cellular localization

Membrane ; Single-pass type I membrane protein .

Research area

All research areas>Neurobiology Antibodies>robo
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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