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Rabbit Anti-ROCK2 Antibody (CSB-PA020059ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Rho kinase 2 Antibody,Rho-associated Antibody, coiled-coil-containing protein kinase 2 Antibody,Rho-associated Antibody, coiled-coil-containing protein kinase II Antibody,ROCK-II Antibody,p164 ROCK-2 Antibody,ROCK2 AntibodyMore alternative names for the antibody
coiled-coil-containing protein kinase 2 antibody|KIAA0619 antibody|p164 ROCK 2 antibody|p164 ROCK-2 antibody|Rho associated coiled coil containing protein kinase 2 antibody|Rho associated protein kinase 2 antibody|Rho associated, coiled coil containing protein kinase II antibody|Rho kinase 2 antibody|Rho-associated antibody|Rho-associated protein kinase 2 antibody|ROCK 2 antibody|Rock II antibody|Rock2 antibody|ROCK2_HUMAN antibody|Rock2m antibody|ROK alpha antibody|ROKalpha antibody
Anti-ROCK2 antibody (ab71598)
Anti-ROCK2 antibody (ab71598)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Rho-associated protein kinase 2 protein (1109-1388AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:9475( Human), Entrez Gene:19878( Mouse), Entrez Gene:25537( Rat), Omim:604002( Human), SwissProt:O75116( Human), SwissProt:P70336( Mouse), SwissProt:Q62868( Rat), Unigene:58617( Human), Unigene:681743( Human), Unigene:276024( Mouse), Unigene:88642( Rat)
|Protein function|| |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization.
|Protein post-translational modifications|| |
Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity. .; Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.
|Protein cellular localization|| |
Cytoplasm. Cell membrane ; Peripheral membrane protein . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. .
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CUSABIO BIOTECH CO.
|Product type|| |
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