Anti-RRM2B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC,IP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RRM2B Antibody (CSB-PA745339ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TP53-inducible ribonucleotide reductase M2 B Antibody,p53-inducible ribonucleotide reductase small subunit 2-like protein Antibody, p53R2 Antibody,RRM2B Antibody,P53R2 Antibody

More alternative names for the antibody
DKFZp686M05248 antibody|MGC102856 antibody|MGC42116 antibody|MTDPS8A antibody|MTDPS8B antibody|p53 inducible ribonucleotide reductase small subunit 2 homolog antibody|p53 inducible ribonucleotide reductase small subunit 2 like protein antibody|P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody|p53 R2 antibody|p53-inducible ribonucleotide reductase small subunit 2-like protein antibody|p53R2 antibody|Ribonucleoside diphosphate reductase M2 subunit B antibody|Ribonucleoside-diphosphate reductase subunit M2 B antibody|Ribonucleotide reductase M2 B (TP53 inducible) antibody|Ribonucleotide reductase M2 B antibody|Ribonucleotide reductase small subunit like 2 p53 inducible antibody|RIR2B_HUMAN antibody|RRM 2B antibody|RRM2B antibody|TP53 inducible ribonucleotide reductase M2 B antibody|TP53-inducible ribonucleotide reductase M2 B antibody
Anti-p53R2 antibody (ab8105)
Close sc-137174|sc-137175|sc-137173|sc-98384|sc-10840|sc-101247|sc-33015|

Recommended applications: ELISA, WB, IHC, IP

Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000

Recommended protocols: check protocols

Name

Anti-RRM2B Antibody

Catalogue No.

CSB-PA745339ESR1HU

Reactivity

Human

Immunogen

Recombinant human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)

Host

Rabbit

Applications

ELISA, WB, IHC, IP

Recommended dilution

Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

40 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:50484( Human), Entrez Gene:382985( Mouse), Entrez Gene:299976( Rat), Omim:604712( Human), SwissProt:Q7LG56( Human), SwissProt:Q6PEE3( Mouse), Unigene:512592( Human), Unigene:24738( Mouse)

Protein function

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. .

Protein tissue specificity

Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. .

Involvement in disease

Mitochondrial DNA depletion syndrome 8A (MTDPS8A) [MIM:612075]: A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Mitochondrial DNA depletion syndrome 8B (MTDPS8B) [MIM:612075]: A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5) [MIM:613077]: A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the ribonucleoside diphosphate reductase small chain family.

Protein cellular localization

Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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