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Rabbit Anti-RRM2B Antibody (CSB-PA745339ESR1HU)
Supplier: CUSABIO BIOTECH CO.
TP53-inducible ribonucleotide reductase M2 B Antibody,p53-inducible ribonucleotide reductase small subunit 2-like protein Antibody, p53R2 Antibody,RRM2B Antibody,P53R2 AntibodyMore alternative names for the antibody
DKFZp686M05248 antibody|MGC102856 antibody|MGC42116 antibody|MTDPS8A antibody|MTDPS8B antibody|p53 inducible ribonucleotide reductase small subunit 2 homolog antibody|p53 inducible ribonucleotide reductase small subunit 2 like protein antibody|P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody|p53 R2 antibody|p53-inducible ribonucleotide reductase small subunit 2-like protein antibody|p53R2 antibody|Ribonucleoside diphosphate reductase M2 subunit B antibody|Ribonucleoside-diphosphate reductase subunit M2 B antibody|Ribonucleotide reductase M2 B (TP53 inducible) antibody|Ribonucleotide reductase M2 B antibody|Ribonucleotide reductase small subunit like 2 p53 inducible antibody|RIR2B_HUMAN antibody|RRM 2B antibody|RRM2B antibody|TP53 inducible ribonucleotide reductase M2 B antibody|TP53-inducible ribonucleotide reductase M2 B antibody
Anti-p53R2 antibody (ab8105)
Anti-p53R2 antibody (ab8105)
Recommended applications: ELISA, WB, IHC, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)
ELISA, WB, IHC, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50484" target="_blank">Entrez Gene:50484( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=382985" target="_blank">Entrez Gene:382985( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=299976" target="_blank">Entrez Gene:299976( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/604712" target="_blank">Omim:604712( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q7LG56" target="_blank">SwissProt:Q7LG56( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q6PEE3" target="_blank">SwissProt:Q6PEE3( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=512592" target="_blank">Unigene:512592( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=24738" target="_blank">Unigene:24738( Mouse)</a>
|Protein function|| |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. .
|Protein tissue specificity|| |
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. .
|Involvement in disease|| |
Mitochondrial DNA depletion syndrome 8A (MTDPS8A) [MIM:612075]: A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Mitochondrial DNA depletion syndrome 8B (MTDPS8B) [MIM:612075]: A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5) [MIM:613077]: A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the ribonucleoside diphosphate reductase small chain family.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
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|Product type|| |
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