Anti-RSPO1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-RSPO1 Antibody (CSB-PA644834DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Roof plate-specific spondin-1 Antibody,hRspo1 Antibody,RSPO1 Antibody

More alternative names for the antibody
CRISTIN3 antibody|FLJ40906 antibody|hRspo1 antibody|R spondin homolog (Xenopus laevis) antibody|R spondin homolog antibody|R spondin1 antibody|R-spondin-1 antibody|Roof plate specific spondin antibody|Roof plate-specific spondin-1 antibody|RP11-566C13.1 antibody|RSPO antibody|Rspo1 antibody|RSPO1_HUMAN antibody
Anti-RSPO1 antibody (ab106556)
Close sc-49090|sc-49092|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-RSPO1 Antibody

Catalogue No.

CSB-PA644834DSR1HU

Reactivity

Human

Immunogen

Recombinant human R-spondin-1 protein (21-263AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

28 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:284654( Human), Entrez Gene:192199( Mouse), Entrez Gene:313589( Rat), Omim:609595( Human), SwissProt:Q2MKA7( Human), SwissProt:Q9Z132( Mouse), Unigene:135015( Human), Unigene:42202( Mouse)

Protein function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .

Protein tissue specificity

Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .

Involvement in disease

Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the R-spondin family. The FU repeats are required for activation and stabilization of beta-catenin.

Protein cellular localization

Secreted . Nucleus . Note=Seems to mainly localize to nucleoli. .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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