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Rabbit Anti-SAP18 Antibody (CSB-PA020695ESR2HU)
Supplier: CUSABIO BIOTECH CO.
18 kDa Sin3-associated polypeptide;2HOR0202;Cell growth-inhibiting gene 38 protein;Sin3-associated polypeptide p18;SAP18;GIG38 AntibodyMore alternative names for the antibody
18 kDa Sin3-associated polypeptide antibody|2HOR0202 antibody|Cell growth-inhibiting gene 38 protein antibody|Histone deacetylase complex subunit SAP18 antibody|SAP18 antibody|SAP18_HUMAN antibody|Sin3-associated polypeptide p18 antibody
Anti-SAP18 antibody (ab31748)
Anti-SAP18 antibody (ab31748)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Histone deacetylase complex subunit SAP18 protein (2-153AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:615692( Cow), Entrez Gene:10284( Human), Entrez Gene:20220( Mouse), Entrez Gene:290284( Rat), Entrez Gene:393693( Zebrafish), Omim:602949( Human), SwissProt:Q3T022( Cow), SwissProt:O00422( Human), SwissProt:O55128( Mouse), Unigene:524899( Human), Unigene:30173( Mouse), Unigene:344671( Mouse), Unigene:74373( Rat)
|Protein function|| |
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. .
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the SAP18 family.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Nucleus speckle . Note=Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198). .
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CUSABIO BIOTECH CO.
|Product type|| |
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