Anti-SCN8A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SCN8A Antibody (CSB-PA891989ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Sodium channel protein type 8 subunit alpha Antibody,Sodium channel protein type VIII subunit alpha Antibody,Voltage-gated sodium channel subunit alpha Nav1.6 Antibody,SCN8A Antibody,MED Antibody

More alternative names for the antibody
CerIII antibody|CIAT antibody|EIEE13 antibody|hNa6/Scn8a voltage gated sodium channel antibody|MED antibody|Motor endplate disease antibody|NaCh 6 antibody|NaCh6 antibody|Nav 1.6 antibody|Nbna1 antibody|peripheral nerve protein type 4 antibody|PN 4 antibody|PN4 antibody|SCN8A antibody|SCN8A_HUMAN antibody|Sodium channel protein type 8 alpha subunit antibody|Sodium channel protein type 8 subunit alpha antibody|Sodium channel protein type VIII alpha subunit antibody|Sodium channel protein type VIII subunit alpha antibody|Sodium channel voltage gated type VIII alpha antibody|Sodium channel voltage gated type VIII alpha polypeptide antibody|Sodium channel voltage gated type VIII alpha subunit antibody|Voltage gated sodium channel subunit alpha Nav1.6 antibody|Voltage-gated sodium channel subunit alpha Nav1.6 antibody
Anti-Nav1.6 antibody (ab65166)
Close sc-168694|sc-81884|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SCN8A Antibody

Catalogue No.

CSB-PA891989ESR1HU

Reactivity

Human

Immunogen

Recombinant human Sodium channel protein type 8 subunit alpha protein (1350-1440AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

225 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6334( Human), Entrez Gene:20273( Mouse), Entrez Gene:29710( Rat), Omim:600702( Human), SwissProt:Q9UQD0( Human), SwissProt:Q9WTU3( Mouse), SwissProt:O88420( Rat), Unigene:710638( Human), Unigene:385012( Mouse), Unigene:91216( Rat)

Protein function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. .

Protein tissue specificity

Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. .

Involvement in disease

Cognitive impairment with or without cerebellar ataxia (CIAT) [MIM:614306]: A disorder characterized by markedly delayed cognitive and motor development, attention deficit disorder, and cerebellar ataxia. Features include bilateral esophoria, strabismatic amblyopia, unsustained gaze evoked nystagmus on horizontal gaze, ataxic gait, dysmetria in the upper limbs and dysarthria, with normal strength, tone, and reflexes. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Epileptic encephalopathy, early infantile, 13 (EIEE13) [MIM:614558]: A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. EIEE13 is a severe form consisting of early-onset seizures, features of autism, intellectual disability, ataxia, and sudden unexplained death in epilepsy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Seizures, benign familial infantile, 5 (BFIS5) [MIM:617080]: A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS5 inheritance is autosomal dominant. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Protein post-translational modifications

May be ubiquitinated by NEDD4L; which would promote its endocytosis. .; Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein .; Isoform 5: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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