Anti-SH3GLB1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SH3GLB1 Antibody (CSB-PA878084ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Bax-interacting factor 1 Antibody,Bif-1 Antibody,SH3 domain-containing GRB2-like protein B1 Antibody,SH3GLB1 Antibody,CGI-61 Antibody

More alternative names for the antibody
Bax interacting factor 1 antibody|Bax-interacting factor 1 antibody|Bif 1 antibody|Bif-1 antibody|CGI 61 antibody|dJ612B15.2 antibody|Endophilin B1 antibody|Endophilin-B1 antibody|PPP1R70 antibody|Protein phosphatase 1 regulatory subunit 70 antibody|SH3 containing protein SH3GLB1 antibody|SH3 domain GRB2 like endophilin B1 antibody|SH3 domain-containing GRB2-like protein B1 antibody|Sh3glb1 antibody|SH3p13 antibody|SHLB1_HUMAN antibody
Anti-Bif antibody – C-terminal (ab154236)
Close sc-52924|sc-393191|sc-374146|sc-134843|sc-50565|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SH3GLB1 Antibody

Catalogue No.

CSB-PA878084ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Endophilin-B1 protein (1-365AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

40 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:51100( Human), Entrez Gene:54673( Mouse), Omim:609287( Human), SwissProt:Q9Y371( Human), SwissProt:Q9JK48( Mouse), Unigene:136309( Human), Unigene:271775( Mouse), Unigene:440295( Mouse)

Protein function

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). .

Protein tissue specificity

Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. .

Protein sequence and domain

Belongs to the endophilin family. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.; The SH3 domain is required and sufficient for the interaction with UVRAG.

Protein post-translational modifications

Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. .

Protein cellular localization

Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane . Midbody . Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140). .

Research area

All research areas>Transport and Trafficking>Endophilin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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