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Rabbit Anti-SH3GLB1 Antibody (CSB-PA878084ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Bax-interacting factor 1 Antibody,Bif-1 Antibody,SH3 domain-containing GRB2-like protein B1 Antibody,SH3GLB1 Antibody,CGI-61 AntibodyMore alternative names for the antibody
Bax interacting factor 1 antibody|Bax-interacting factor 1 antibody|Bif 1 antibody|Bif-1 antibody|CGI 61 antibody|dJ612B15.2 antibody|Endophilin B1 antibody|Endophilin-B1 antibody|PPP1R70 antibody|Protein phosphatase 1 regulatory subunit 70 antibody|SH3 containing protein SH3GLB1 antibody|SH3 domain GRB2 like endophilin B1 antibody|SH3 domain-containing GRB2-like protein B1 antibody|Sh3glb1 antibody|SH3p13 antibody|SHLB1_HUMAN antibody
Anti-Bif antibody – C-terminal (ab154236)
Anti-Bif antibody – C-terminal (ab154236)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Endophilin-B1 protein (1-365AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). .
|Protein tissue specificity|| |
Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. .
|Protein sequence and domain|| |
Belongs to the endophilin family. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.; The SH3 domain is required and sufficient for the interaction with UVRAG.
|Protein post-translational modifications|| |
Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. .
|Protein cellular localization|| |
Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane . Midbody . Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140). .
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CUSABIO BIOTECH CO.
|Product type|| |
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